Virologica Sinica

, Volume 32, Issue 1, pp 80–88

A new strain of Crimean-Congo hemorrhagic fever virus isolated from Xinjiang, China

  • Rong Guo
  • Shu Shen
  • Yanfang Zhang
  • Junming Shi
  • Zhengyuan Su
  • Dan Liu
  • Jinliang Liu
  • Juan Yang
  • Qiguo Wang
  • Zhihong Hu
  • Yujiang Zhang
  • Fei Deng
Research article

DOI: 10.1007/s12250-016-3936-9

Cite this article as:
Guo, R., Shen, S., Zhang, Y. et al. Virol. Sin. (2017) 32: 80. doi:10.1007/s12250-016-3936-9

Abstract

Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. CCHFV is widely distributed in countries around the world. Outbreaks of CCHFV infection in humans have occurred in prior years in Xinjiang Province, China. Epidemiological surveys have detected CCHFV RNA in ticks and animals; however, few isolates were identified. In this study, we identified and isolated a new CCHFV strain from Hyalomma asiaticum asiaticum ticks collected from north of Tarim Basin in Xinjiang, China. A preliminary investigation of infection and antigens expression of CCHFV was performed in newborn mice. The target tissues for CCHFV replication in newborn mice were identified. The analysis of the phylogenetic relationships with other Chinese strains suggested that diverse genotypes of CCHFV have circulated in Xinjiang for years. These findings provide important insights into our understanding of CCHFV infection and evolution as well as disease prevention and control for local residents.

Keywords

Crimean-Congo hemorrhagic fever virus (CCHFV) newborn mice genotype phylogenetic analysis 
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Supplementary material

12250_2016_3936_MOESM1_ESM.pdf (116 kb)
A new strain of Crimean-Congo hemorrhagic fever virus isolated from Xinjiang, China

Copyright information

© Wuhan Institute of Virology, CAS and Springer Science+Business Media Singapore 2017

Authors and Affiliations

  • Rong Guo
    • 1
  • Shu Shen
    • 2
  • Yanfang Zhang
    • 2
  • Junming Shi
    • 2
  • Zhengyuan Su
    • 2
  • Dan Liu
    • 3
  • Jinliang Liu
    • 2
  • Juan Yang
    • 2
  • Qiguo Wang
    • 1
  • Zhihong Hu
    • 1
  • Yujiang Zhang
    • 1
  • Fei Deng
    • 2
  1. 1.The Center for Disease Control and Prevention of Xinjiang Uygur Autonomous’ RegionUrumqi, XinjiangChina
  2. 2.State Key Laboratory of Virology, Wuhan Institute of VirologyChinese Academy of SciencesWuhanChina
  3. 3.School of MedicineWuhan University of Science and TechnologyWuhanChina

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