Virologica Sinica

, Volume 31, Issue 2, pp 118–130

Phylogenetic analysis revealed the central roles of two African countries in the evolution and worldwide spread of Zika virus

  • Shu Shen
  • Junming Shi
  • Jun Wang
  • Shuang Tang
  • Hualin Wang
  • Zhihong Hu
  • Fei Deng
Research Article

DOI: 10.1007/s12250-016-3774-9

Cite this article as:
Shen, S., Shi, J., Wang, J. et al. Virol. Sin. (2016) 31: 118. doi:10.1007/s12250-016-3774-9

Abstract

Recent outbreaks of Zika virus (ZIKV) infections in Oceania's islands and the Americas were characterized by high numbers of cases and the spread of the virus to new areas. To better understand the origin of ZIKV, its epidemic history was reviewed. Although the available records and information are limited, two major genetic lineages of ZIKV were identified in previous studies. However, in this study, three lineages were identified based on a phylogenetic analysis of all virus sequences from GenBank, including those of the envelope protein (E) and non-structural protein 5 (NS5) coding regions. The spatial and temporal distributions of the three identified ZIKV lineages and the recombination events and mechanisms underlying their divergence and evolution were further elaborated. The potential migration pathway of ZIKV was also characterized. Our findings revealed the central roles of two African countries, Senegal and Cote d'Ivoire, in ZIKV evolution and genotypic divergence. Furthermore, our results suggested that the outbreaks in Asia and the Pacific islands originated from Africa. The results provide insights into the geographic origins of ZIKV outbreaks and the spread of the virus, and also contribute to a better understanding of ZIKV evolution, which is important for the prevention and control of ZIKV infections.

Keywords

Flaviviridae Zika virus (ZIKV) phylogenetic analysis lineages recombination migration 

Supplementary material

12250_2016_3774_MOESM1_ESM.pdf (112 kb)
Supplementary material, approximately 113 KB.

Copyright information

© Wuhan Institute of Virology, CAS and Springer Science+Business Media Singapore 2016

Authors and Affiliations

  • Shu Shen
    • 1
  • Junming Shi
    • 1
  • Jun Wang
    • 1
  • Shuang Tang
    • 1
  • Hualin Wang
    • 1
  • Zhihong Hu
    • 1
  • Fei Deng
    • 1
  1. 1.State Key Laboratory of Virology, Wuhan Institute of VirologyChinese Academy of SciencesWuhanChina