Virologica Sinica

, Volume 31, Issue 4, pp 300–305

Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds, 2014–2015

  • Yuhai Bi
  • Jianjun Chen
  • Zhenjie Zhang
  • Mingxin Li
  • Tianlong Cai
  • Kirill Sharshov
  • Ivan Susloparov
  • Alexander Shestopalov
  • Gary Wong
  • Yubang He
  • Zhi Xing
  • Jianqing Sun
  • Di Liu
  • Yingxia Liu
  • Lei Liu
  • Wenjun Liu
  • Fumin Lei
  • Weifeng Shi
  • George F. Gao
Research Article

DOI: 10.1007/s12250-016-3750-4

Cite this article as:
Bi, Y., Chen, J., Zhang, Z. et al. Virol. Sin. (2016) 31: 300. doi:10.1007/s12250-016-3750-4

Abstract

A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015. Based on the genetic and phylogenetic analyses, the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA, a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin. The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain (A/Alberta/01/2014). Further analysis showed that similar viruses have been circulating in wild birds in China, Russia, Dubai (Western Asia), Bulgaria and Romania (Europe), as well as domestic poultry in some regions of Africa. The affected areas include the Central Asian, East Asian-Australasian, West Asian-East African, and Black Sea/Mediterranean flyways. These results show that the novel Clade 2.3.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds, thus posing a serious threat to wild birds and potentially humans.

Keywords

H5N1 highly pathogenic avian influenza virus Clade 2.3.2.1c outbreak migratory birds 

Supplementary material

12250_2016_3750_MOESM1_ESM.pdf (1.4 mb)
Supplementary material, approximately 3.96 MB.
12250_2016_3750_MOESM2_ESM.xls (30 kb)
Supplementary material, approximately 32 KB.

Copyright information

© Wuhan Institute of Virology, CAS and Springer Science+Business Media Singapore 2016

Authors and Affiliations

  • Yuhai Bi
    • 1
    • 3
    • 6
  • Jianjun Chen
    • 2
    • 7
  • Zhenjie Zhang
    • 4
  • Mingxin Li
    • 2
  • Tianlong Cai
    • 5
  • Kirill Sharshov
    • 7
  • Ivan Susloparov
    • 7
  • Alexander Shestopalov
    • 7
  • Gary Wong
    • 3
  • Yubang He
    • 8
  • Zhi Xing
    • 8
  • Jianqing Sun
    • 8
  • Di Liu
    • 3
  • Yingxia Liu
    • 1
  • Lei Liu
    • 1
  • Wenjun Liu
    • 3
    • 6
  • Fumin Lei
    • 5
    • 6
  • Weifeng Shi
    • 4
  • George F. Gao
    • 1
    • 3
    • 6
    • 9
  1. 1.Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious DiseaseShenzhen Third People’s HospitalShenzhenChina
  2. 2.CAS Key Laboratory of Special Pathogens and BiosafetyWuhan Institute of Virology Chinese Academy of SciencesWuhanChina
  3. 3.CAS Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of MicrobiologyChinese Academy of SciencesBeijingChina
  4. 4.Institute of Pathogen BiologyTaishan Medical CollegeTaishanChina
  5. 5.CAS Key Laboratory of Zoological Systematics and Evolution, Institute of ZoologyChinese Academy of SciencesBeijingChina
  6. 6.Center for Influenza Research and Early-warning (CASCIRE)Chinese Academy of SciencesBeijingChina
  7. 7.Research Institute of Experimental and Clinical MedicineNovosibirsk State UniversityNovosibirskRussia
  8. 8.Qinghai Lake National Nature ReserveState Forestry AdministrationXiningChina
  9. 9.Office of Director-General, Chinese Center for Disease Control and Prevention (China CDC), and Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseZhejiang UniversityHangzhouChina