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The miRNAs of Herpes Simplex Virus (HSV)

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Virologica Sinica

Abstract

Herpes simplex virus (HSV) is a group of common human pathogens with two serotypes HSV-1 and HSV-2. The prevalence of HSV is worldwide. It primarily infects humans through epithelial cells, when it introduces a latent infection into the nervous system. During viral latency, only a region known as the latency-associated transcript (LAT) is expressed. The discovery of HSV miRNAs helps to draw a larger picture of the infection and pathogenesis of the virus. This review summarizes miRNAs found in HSV-1 and HSV-2 so far. The functional studies of miRNAs in HSV to date indicate that they play a stage-specific role coordinated with viral proteins to maintain the virus life cycle.

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Authors and Affiliations

  1. Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming, 650118, China

    Le Sun & Qihan Li

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  1. Le Sun
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  2. Qihan Li
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Correspondence to Le Sun.

Additional information

Foundation items: This work was supported by the National Natural Sciences Foundation of China (No. 30670094 and 30700028) and Youth Science Research Foundation of PUMC (No. 2012X23).

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Sun, L., Li, Q. The miRNAs of Herpes Simplex Virus (HSV). Virol. Sin. 27, 332–337 (2012). https://doi.org/10.1007/s12250-012-3266-5

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  • DOI: https://doi.org/10.1007/s12250-012-3266-5

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