Virologica Sinica

, Volume 24, Issue 5, pp 359–414

Encyclopedia of Autographa californica nucleopolyhedrovirus genes

  • David P. A. Cohen
  • Martin Marek
  • Bryn G. Davies
  • Just M. Vlak
  • Monique M. van Oers
Article

DOI: 10.1007/s12250-009-3059-7

Cite this article as:
Cohen, D.P.A., Marek, M., Davies, B.G. et al. Virol. Sin. (2009) 24: 359. doi:10.1007/s12250-009-3059-7

Abstract

The Autographa californica multiple capsid nucleopolyhedrovirus (AcMNPV) was the first baculovirus for which the complete nucleotide sequence became known. Since then 15 years lapsed and much research has been performed to elucidate putative functions of the annotated open reading frames of this virus and this endeavour is still ongoing. AcMNPV is the most well-known and well-studied baculovirus species, not in the least for its application as a vector for the high-level expression of foreign genes in insect cells. This article is the first monograph of a single baculovirus and gives a current overview of what is known about the 151 AcMNPV ORFs, including (putative) function and temporal and spatial presence of transcripts and protein. To date 60 ORFs have a proven function, another 19 ORFs have homologs for which functions are known in other baculoviruses and 72 ORFs are still enigmatic. This paper should assist the reader in quickly finding the essentials of AcMNPV.

Key words

Baculovirus Autographa californica multiple capsid nucleopolyhedrovirus(AcMNPV) Functional genomics Review 

CLC number

R373 

Copyright information

© Wuhan Institute of Virology, CAS and Springer Berlin Heidelberg 2009

Authors and Affiliations

  • David P. A. Cohen
    • 1
  • Martin Marek
    • 1
    • 2
  • Bryn G. Davies
    • 3
  • Just M. Vlak
    • 1
  • Monique M. van Oers
    • 1
  1. 1.Laboratory of ViroloWageningen UniversitywageningenThe Netherlands
  2. 2.Department of Bioprocess DevelopmentGénéthonEvryFrance
  3. 3.YCR Cancer Research, Dept. of BiologyUniversity of YorkHeslington, YorkUK