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Angiogenesis, Kaposi’s sarcoma and Kaposi’s sarcoma-associated herpesvirus

  • Published:
Virologica Sinica

Abstract

Tumor angiogenesis is the uncontrolled growth of blood vessels in tumors, serving to supply nutrients and oxygen, and remove metabolic wastes. Kaposi’s sarcoma (KS), a multifocal angioproliferative disorder characterized by spindle cell proliferation, neo-angiogenesis, inflammation, and edema, is associated with infection by Kaposi’s sarcoma-associated herpesvirus (KSHV). Recent studies indicate that KSHV infection directly promotes angiogenesis and inflammation through an autocrine and paracrine mechanism by inducing pro-angiogenic and pro-inflammatory cytokines. Many of these cytokines are also expressed in KS lesions, implicating a direct role of KSHV in the pathogenesis of this malignancy. Several KSHV genes are involved in KSHV-induced angiogenesis. These studies have provided insights into the pathogenesis of KS, and identified potential therapeutic targets for this malignancy.

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Authors and Affiliations

  1. Tumor Virology Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China

    Tao Kang, Shou-jiang gao & Lin-ding Wang

  2. Graduate School of the Chinese Academy of Sciences, Beijing, 100039, China

    Tao Kang

  3. Tumor Virology Program, Greehey Children’s Cancer Research Institute and Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

    Tao Kang, Feng-chun Ye, Shou-jiang gao & Lin-ding Wang

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  1. Tao Kang
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  2. Feng-chun Ye
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  3. Shou-jiang gao
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Correspondence to Shou-jiang gao or Lin-ding Wang.

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Foundation items: The Knowledge Innovation Program of the Chinese Academy of Sciences Chinese Academy of Sciences (0702121YJ1); Open Research Fund Program of the State Key Laboratory of Virology of China (2007013); A Type B Outstanding Abroad Young Scientist Award (30328001) from the National Science Foundation of China; and grants from the National Institutes of Health (CA096512, CA124332, CA119889 and DE017333).

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Kang, T., Ye, Fc., gao, Sj. et al. Angiogenesis, Kaposi’s sarcoma and Kaposi’s sarcoma-associated herpesvirus. Virol. Sin. 23, 449–458 (2008). https://doi.org/10.1007/s12250-008-2998-8

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  • DOI: https://doi.org/10.1007/s12250-008-2998-8

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