Abstract
Nucleoside analogues have been the mainstay of clinical treatment of herpes simplex virus 1 (HSV-1) infections since their development. However, the emergence of drug resistant strains has underlined the urgency of the discovery of novel anti-HSV-1 drugs. Natural products, which provided many novel drug leads, are known to be an important source of anti-HSV-1 agents. Herein, we present an overview of natural products with anti-HSV-1 activities isolated from a variety of plants reported in recent years. Several different compounds, mainly belonging to the three groups of polysaccharides, polyphenols and terpenes, showed antiviral effects against HSV-1, indicating their potential to be promising anti-HSV-1 agents.
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Adhikari U, Mateu C G, Chattopadhyay K, et al. 2006. Structure and antiviral activity of sulfated fucans from Stoechospermum marginatum. Phytochemistry, 67(22): 2474–2482.
Alban S, Franz G. 2002. Partial synthetic glucan sulfates as potential new antithrombotics. Biomacromolecules, 2(2): 354–361.
Barbosa J P, Pereira R C, Abrantes J L, et al. 2004. In vitro antiviral diterpenes from the Brazilian brown alga Dictyota pfaffii. Planta Med, 70(9): 856–860.
Chattopadhyay K, Mateu C G, Mandal P, et al. 2007. Galactan sulfate of Grateloupia indica: Isolation, structural features and antiviral activity. Phytochemistry, 68(10): 1428–1435.
Cooper E L. 2001. Drug discovery, CAM and natural products. eCAM, 1(3): 215–217.
Corey L, Adams H G, Brown Z A, et al. 1983. Genital herpes simplex virus infections: clinical manifestations, course, and complications. Ann Intern Med, 98(6): 958–972.
Fatahzadeh M, Schwartz R A. 2007. Human herpes simplex virus infections: Epidemiology, pathogenesis, symptomatology, diagnosis, and management. J Am Acad Dermatol, 57(5): 737–763.
Filho I C, Cortez D A G, Ueda-Nakamura T, et al. 2008. Antiviral activity and mode of action of a peptide isolated from Sorghum bicolor. Phytomedicine, 15(3): 202–208.
Fritz D, Venturi C R, Cargnin S, et al. 2007. Herpes virus inhibitory substances from Hypericum connatum Lam., a plant used in southern Brazil to treat oral lesions. J Ethnopharmaco, 113(3): 517–520.
Grabley S, Thiericke R. 2000. Drug Discovery from Nature, Berlin: Springer, p3–p37.
Groth T, Wagenknecht W. 2001. Anticoagulant potential of regioselective cellulose. Biomaterials, 22(12): 2719–2729.
Gu C Q, Li J W, Chao F, et al. 2007. Isolation, identification and function of a novel anti-HSV-1 protein from Grifola frondosa. Antiviral Res, 75(3):250–257.
Hayashi K, Nakano T, Hashimoto M, et al. 2008. Defensive effects of a fucoidan from brown alga Undaria pinnatifida against herpes simplex virus infection. Int Immunopharmacol, 8(1): 109–116.
Ikeda T, Yokomizo K, Okawa M, et al. 2005. Anti-herpes virus type 1 activity of oleanane-type triterpenoids. Biol Pharm Bull, 28(9): 1779–1781.
Isaacs C E, Wen G Y, Xu W, et al. 2008. Epigallocatechin Gallate Inactivates Clinical Isolates of Herpes Simplex Virus. Antimicrob Agents Chemother, 52(3): 962–970.
Kalinyak J E, Fleagle G, Docherty J J. 1977. Incidence and distribution of herpes simplex virus types 1 and 2 from genital lesions in college women. J Med Virol, 1(3): 175–181.
Kanekiyo K, Hayashi K, Takenaka H, et al. 2007. Anti-herpes simplex virus target of an acidic polysaccharide, nostoflan, from the edible blue-green alga Nostoc flagelliforme. Biol Pharm Bull, 30(8): 1573–1575.
Kanekiyo K, Lee J B, Hayashi K, et al. 2005. Isolation of an antiviral polysaccharide, nostoflan, from a terrestrial cyanobacterium, Nostoc flagelliforme. J Nat Prod, 68(7): 1037–1041.
Khan M T H, Ather A, Kenneth D, et al. 2005. Extracts and molecules from medicinal plants against herpes simplex viruses. Antiviral Res, 67: 107–119.
Krawczyk E, Luczak M, Majewska A. 2005. Antiviral and cytotoxic activities of new derivatives of natural sesquiterpenes and taxol. Med Dosw Mikrobiol, 57(1): 93–99.
Krawczyk E, Luczak M, Kniotek M, et al. 2005. Cytotoxic, antiviral (in-vitro and in-vivo), immunomodulatory activity and influence on mitotic divisions of three taxol derivatives: 10-deacetyl-baccatin III, methyl (N-benzoyl-(2′R, 3′S)-3′-phenylisoserinate) and N-benzoyl-(2′R,3′S)-3′-phenylisoserine. J Pharm Pharmacol, 57(6): 791–797.
Kutluay S B, Doroghazi J, Roemer M E, et al. 2008. Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity. Virology, 373(2): 239–247.
Lee J B, Hou X L, Hayashi K, et al. 2007. Effect of partial desulfation and oversulfation of sodium spirulan on the potency of anti-herpetic activities. Carbohyd Polym, 69(4): 651–658.
Likhitwitayawuid K, Chaiwiriya S, Sritularak B, et al. 2006. Antiherpetic flavones from the heartwood of Artocarpus gomezianus. Chem Biodivers, 3(10): 1138–1143.
Li Y L, Jiang R W, Ooi L S M, et al. 2007. Antiviral Triterpenoids from the Medicinal Plant Schefflera heptaphylla. Phytother Res, 21(5): 466–470.
Li Y, Leung K T, Yao F, et al. 2006. Antiviral flavans from the leaves of Pithecellobium clypearia. J Nat Prod, 69(5): 833–835.
Li Z, Liu J, Zhao Y. 2005. Possible mechanism underlying the antiherpetic activity of a proteoglycan isolated from the mycelia of Ganoderma lucidum in vitro. J Biochem Mol Biol, 38(1): 34–40.
Lindequist U, Niedermeyer T, Jülich W D. 2005. The pharmacological potential of mushrooms. eCAM, 2(3): 28–99.
Lyu S Y, Rhim J Y, Park W B. 2005. Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro. Arch Pharm Res, 28(11): 1293–1301.
Manach C, Scalbert A, Morand C, et al. 2004. Polyphenols: food sources and bioavailability. Am J Clin Nutr, 79(5): 727–747.
Mandal P, Mateu C G, Chattopadhyay K, et al. 2007. Structural features and antiviral activity of sulphated fucans from the brown seaweed Cystoseira indica. Antivir Chem Chemother, 18(3): 153–162.
Matsuhiro B, Conte A F, Damonte E B, et al. 2005. Structural analysis and antiviral activity of a sulfated galactan from the red seaweed Schizymenia binderi (Gigartinales, Rhodophyta). Carbohydr Res, 340(15): 2392–2402.
Müller V, Chávez J H, Reginatto F H, et al. 2007. Evaluation of antiviral activity of South American plant extracts against herpes simplex virus type 1 and rabies virus. Phytother Res, 21(10): 970–974.
Newman D J, Cragg G M, Snader K M. 2000. The influence of natural products upon drug discovery. Nat Prod Rep, 17(3): 215–234.
Newman D J, Cragg G M. 2007. Natural Products as Sources of New Drugs over the Last 25 Years. J Nat Prod, 70(3): 461–477.
Park J, Kurokawa M, Shiraki K, et al. 2005. Antiviral activity of the marine alga Symphyocladia latiuscula against herpes simplex virus (HSV-1) in vitro and its therapeutic efficacy against HSV-1 infection in mice. Biol Pharm Bull, 28(12): 2258–2262.
Pujol C A, Scolaro L A, Ciancia M, et al. 2006. Antiviral activity of a carrageenan from Gigartina skottsbergii against intraperitoneal murine herpes simplex virus infection. Planta Med, 72(2): 121–125.
Savi L A, Barardi C R M, Simões C M O. 2006. Evaluation of Antiherpetic Activity and Genotoxic Effects of Tea Catechin Derivatives. J Agric Food Chem, 54(7): 2552–2557.
Soares A R, Abrantes J L, Lopes Souza T M, et al. 2007. In vitro antiviral effect of meroditerpenes isolated from the Brazilian seaweed Stypopodium zonale (Dictyotales). Planta Med, 73(11): 1221–1224.
Spector F C, Liang L, Giordano H, et al. 1998. Inhibition of Herpes Simplex Virus Replication by a 2-Amino Thiazole via Interactions with the Helicase Component of the UL5-UL8-UL52 Complex. J Virol, 72(9): 6979–6987.
Tolo F M, Rukunga G M, Muli F W, et al. 2006. Anti-viral activity of the extracts of a Kenyan medicinal plant Carissa edulis against herpes simplex virus. J Ethnopharmacol, 104(1–2): 92–99.
Uozaki M, Yamasaki H, Katsuyama Y, et al. 2007. Antiviral effect of octyl gallate against DNA and RNA viruses. Antiviral Res, 73(2): 85–91.
Wiart C, Kumar K, Yusof M Y, et al. 2005. Antiviral properties of ent-labdene diterpenes of Andrographis paniculata nees, inhibitors of herpes simplex virus type 1. Phytother Res, 19(12): 1069–1070.
Yang C M, Cheng H Y, Lin T C, et al. 2007. The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-β-D-glucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection. J Ethnop-harmaco, 110(3): 555–558.
Yamaguchi K, Honda M, Ikigai H, et al. 2002. Inhibitory effects of (−)-epigallocatechin gallate on the life cycle of human immunodeficiency virus type 1 (HIV-1). Antiviral Res, 53(1): 19–34.
Yoosook C, Chantratita W, Rimdusit P. 1989. Recovery frequencies of herpes simplex virus Types 1 and 2 from symptomatic and asymptomatic genital herpes cases and antiviral sensitivities of isolates. J Med Assoc Thailand, 72(10): 572–576.
Zhang Y, But P P, Ooi V E, et al. 2007. Chemical properties, mode of action, and in vivo anti-herpes activities of a lignin-carbohydrate complex from Prunella vulgaris. Antiviral Res, 75(3): 242–249.
Zhu W, Chiu L C M, Ooi V E C, et al. 2006. Antiviral property and mechanisms of a sulphated polysaccharide from the brown alga Sargassum patens against Herpes simplex virus type 1. Phytomedicine, 13(9–10): 695–701.
Ziyaeyan M, Alborzi A, Japoni A, et al. 2007. Frequency of acyclovir-resistant herpes simplex viruses isolated from the general immunocompetent population and patients with acquired immunodeficiency syndrome. Int J Dermatol, 46(12): 1263–1266.
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Foundation item: Joint funds of National Natural Science Foundation of China (U0632010)
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Xiang, Yf., Pei, Y. & Wang, Yf. Current status of natural products from plants as anti-herpes simplex virus 1 agents. Virol. Sin. 23, 305–314 (2008). https://doi.org/10.1007/s12250-008-2962-7
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DOI: https://doi.org/10.1007/s12250-008-2962-7