Abstract
This paper presents an overview of the recent research activities carried on at INRIM in the field of metrology for healthcare, aiming at supporting therapeutic and diagnostic techniques based on electromagnetics and nanomagnetics. Attention is here specifically focused on three research topics, respectively related to electromagnetic dosimetry for MR-safety, production and characterization of magnetic Ni80Fe20 nanodisks for biomedical applications and development of modeling tools to support the design of novel biosensors.
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Biro O, Preis K, Renhart W, Vrisk G, Richter KR (1993) Computation of 3-D current driven skin effect problems using a current vector potential. IEEE Trans Magn 29(2):1325–1328
Bottauscio O, Chiampi M, and Zilberti L (2014) Massively parallelized boundary element simulation of voxel-based human models exposed to MRI fields. IEEE Trans Magn 50(2): 7025504
Cabot E, Lloyd T, Christ A, Kainz W, Douglas M (2013) Evaluation of the RF heating of a generic deep brain stimulator exposed in 1.5 T magnetic resonance scanners. Bioelectromagnetics 34(2):104–113
Collins CM, Smith MB (2003) Spatial resolution of numerical models of man and calculated specific absorption rate using the FDTD method: a study at 64 MHz in a magnetic resonance imaging coil. J Magn Reson Imaging 18:383–388
Collins CM, Wang Z (2011) Calculation of radiofrequency electromagnetic fields and their effects in MRI of human subjects. Magn Reson Med 65:1470–1482
Corte-León H, Nabaei V, Manzin A, Fletcher J, Krzysteczko P, Schumacher HW, Kazakova O (2014) Anisotropic magnetoresistance state space of permalloy nanowires with domain wall pinning geometry. Sci Rep 4: 6045
Corte-León H, Krzysteczko P, Schumacher HW, Manzin A, Antonov V, Kazakova O (2015) Magnetic bead detection using domain wall-based nanosensor. J Appl Phys (in press)
Donolato M et al (2009) Nanosized corners for trapping and detecting magnetic nanoparticles. Nanotechnology 20:385501
Folks L et al (2009) Near-surface nanoscale InAs Hall cross sensitivity to localized magnetic and electric fields. J Phys: Condens Matter 21:255802
Freitas PP, Ferreira R, Cardoso S, Cardoso F (2007) Magnetoresistive sensors. J Phys Condens Matter 19: 165221
Giordano D, Zilberti L, Borsero M, Chiampi M, Bottauscio O (2014) Experimental validation of MRI dosimetric simulations in phantoms including metallic objects. IEEE Trans Magn 50(11): 5101504
Hasgall PA, Neufeld E, Gosselin MC, Klingenböck A, Kuster N (2013) IT’IS Database for thermal and electromagnetic parameters of biological tissues. Version 2.3, February 11th. www.itis.ethz.ch/database
Huang HT, Ger TR, Lin YH, Wei ZH (2013) Single cell detection using a magnetic zigzag nanowire biosensor. Lab Chip 13:3098–3104
Huang L, Zhang Z, Chen B, Ma X, Zhong H, Peng LM (2014) Ultra-sensitive graphene Hall elements. Appl Phys Lett 104:183106
International Commission on non-Ionizing Radiation Protection (2014) Guidelines for limiting exposure to electric fields induced by movement of the human body in a static magnetic field and by time-varying magnetic fields below 1 Hz. Health Phys 106(3):418–425
IT’IS Foundation Virtual family dataset (2014) http://www.itis.ethz.ch/news-events/news/latest-news/
Kim DH, Rozhkova EA, Ulasov IV, Bader SD, Rajh T, Lesniak MS, Novosad V (2010) Biofunctionalized magnetic vortex microdisks for targeted cancer cell destruction. Nat Mater 9:165–171
Krakowski MR (1991) Some theorems of the eddy-current theory. Archiv für Elektrotechnik 74:329–334
Llandro J, Palfreyman JJ, Ionescu A, Barnes CHV (2010) Magnetic biosensor technologies for medical applications: a review. Med Biol Eng Comput 48:977–998
Manzin A, Nabaei V, Kazakova O (2012) Modelling and optimization of submicron Hall sensors for the detection of superparamagnetic beads. J Appl Phys 111: 07E513
Manzin A, Nabaei V, Corte-León H, Kazakova O, Krzysteczko P, Schumacher HW (2014) Modeling of anisotropic magnetoresistance properties of permalloy nanostructures. IEEE Trans Magn 50:7100204
Manzin A, Simonetto E, Amato G, Panchal V, Kazakova O (2015) Modeling of graphene Hall effect sensors for microbead detection. J Appl Phys (in press)
Mihajlović G, Aledealat K, Xiong P, von Molnár S, Field M, Sullivan GJ (2007) Magnetic characterization of a single superparamagnetic bead by phase-sensitive micro-Hall magnetometry. Appl Phys Lett 91(17):172518
Mohsin SA, Sheikh NM, Abbas W (2009) MRI induced heating of artificial bone implants. J Electromagnet Wave 23:799–808
Novosad V, Guslienko KY, Shima H, Otani Y, Fukamichi K, Kikuchi N, Kitakami O, Shimada Y (2001) Nucleation and annihilation of magnetic vortices in submicron ferromagnetic dots. IEEE Trans Magn 374:2088–2090
Novosad V, Fradin FY, Roy PE, Buchanan K, Guslienko KY, Bader SD (2005) Magnetic vortex resonance in patterned ferromagnetic dots. Phys Rev B 72:024455
O’Brien L et al (2011) Tunable remote pinning of domain walls in magnetic nanowires. Phys Rev Lett 106:087204
Panchal V, Cox D, Yakimova R, Kazakova O (2013) Epitaxial graphene sensors for detection of small magnetic moments. IEEE Trans Magn 49:97–100
Panchal V, Lartsev A, Manzin A, Yakimova R, Tzalenchuk A, Kazakova O (2014) Visualisation of edge effects in side-gated graphene nanodevices. Sci Rep 4:5881
Pennes HH (1948) Analysis of tissue and arterial blood temperatures in the resting human forearm. J Appl Physiol 1:93–122
Powell J, Papadaki A, Hand J, Hart A, McRobbie D (2012) Numerical simulation of SAR induced around Co-Cr-Mo hip prostheses in situ exposed to RF Fields associated with 1.5 and 3 T MRI body coils. Magn Reson Med 68:960–968
Rajkumar RK, Manzin A, Cox DC, Silva SRP, Tzalenchuk A, Kazakova O (2013) 3-D mapping of sensitivity of graphene Hall devices to local magnetic and electrical fields. IEEE Trans Magn 49:3445–3448
Rajkumar RK, Asenjo A, Panchal V, Manzin A, Iglesias-Freire O, Kazakova O (2014) Magnetic scanning gate microscopy of graphene Hall devices. J Appl Phys 115:172606
Rozhkova EA, Novosad V, Kim DH, Pearson J, Divan R, Rajh T, Bader SD (2009) Ferromagnetic microdisks as carriers for biomedical application. J Appl Phys 105: 07B306
Sanchez-Lopez H, Zilberti L, Bottauscio O, Hand J, Papadaki A, Tang F, Chiampi M, Crozier S (2014) Heating of bilateral hip prostheses in a human body model induced by a multi-axis gradient coil set, Proceedings Joint Annual Meeting ISMRM, Milan (Italy). ISSN 1545-4428: 4878
Schaefers G, and Kugel H (2005) A basic investigation of heating effects on total hip prostheses in combination with a simulated skin contact of the inner thighs during magnetic resonance imaging (MRI) with an 1.5 Tesla MR system. Proc ISMRM Workshop on MRI Safety: Update, Practical Information and Future Implications, McClean, Virginia, USA
Stenschke J, Li D, Thomann M, Schaefers G, Zylka W (2007) A numerical investigation of RF heating effect on implants during MRI compared to experimental measurements. Adv Med Eng 114(1):53–58
Tamanaha CR, Mulvaney SP, Rife JC, Whitman LJ (2008) Magnetic labeling, detection, and system integration. Biosens Bioelectron 24:1–13
Tang CC, Li MY, Li LJ, Chi CC, Chen JC (2011) Characteristics of a sensitive micro-Hall probe fabricated on chemical vapor deposited graphene over the temperature range from liquid-helium to room temperature. Appl Phys Lett 99:112107
Tiberto P, Boarino L, Celegato F, De Leo N, Coïsson M, Vinai F, Allia P (2010) Magnetic and magnetotransport properties of arrays of nanostructured antidots obtained by self-assembling polystyrene nanosphere lithography. J Appl Phys 107: 09B502
Voigt T, Homann H, Katscher U, Doessel O (2012) Patient-individual local SAR determination: in vivo measurements and numerical validation. Magn Reson Med 68(4):1117–1126
Wilkoff BL, Albert T, Lazebnik M, Park SM, Edmonson J et al (2013) Safe magnetic resonance imaging scanning of patients with cardiac rhythm devices: a role for computer modeling. Heart Rhythm 10(12):1815–1821
Xu H, Zhang Z, Shi R, Liu H, Wang Z, Wang S, Peng LM (2013) Batch-fabricated high-performance graphene Hall elements. Sci Rep 3:1207
Zelinski AC, Goyal VK, Adalsteinsson E, Wald LL (2008) Fast, accurate calculation of maximum local N-gram Specific Absorption Rate. Proc Intl Soc Mag Reson Med 16: 1188
Zilberti L, Bottauscio O, Chiampi M, Hand J, Sanchez Lopez H, Crozier S (2014) Collateral thermal effect of MRI-LINAC gradient coils on metallic hip prostheses. IEEE Trans Magn 50(11): 5101704
Acknowledgments
The research activities here described were developed under two Joint Research Projects (JRP) of the European Metrology Research Programme: EMRP-HLT06 “Metrology for next-generation safety standards and equipment in MRI” (2012–2015) and EMRP-IND08 “Metrology for advanced industrial magnetics—MetMags” (2011–2014). EMRP is jointly funded by the EMRP participating countries within EURAMET and the European Union. Funding was also received from the Italian MIUR project P7 “Metrology for therapeutic and diagnostic techniques based on electromagnetic radiation and ultrasound waves” (2014–2016).
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Barrera, G., Borsero, M., Bottauscio, O. et al. Metrology to support therapeutic and diagnostic techniques based on electromagnetics and nanomagnetics. Rend. Fis. Acc. Lincei 26 (Suppl 2), 245–254 (2015). https://doi.org/10.1007/s12210-015-0386-5
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DOI: https://doi.org/10.1007/s12210-015-0386-5