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Plasma heat shock protein 72 as a biomarker of sarcopenia in elderly people

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Cell Stress and Chaperones Aims and scope

Abstract

Sarcopenia is a geriatric syndrome in which there is a decrease of muscle mass and strength with aging. In age-related loss of muscle strength, there are numerous observations supporting the assertion that neural factors mediate muscle strength. A possible contributing cause may be that aging changes systemic extracellular heat shock protein (eHsp)72 activity. The present study was designed to assess the plasma levels of eHsp72 in elderly people and to investigate its potential interaction with components of sarcopenia. A total of 665 men and women participated in an official medical health examination and an integrated health examination, including psychological and physical fitness tests. Blood samples were assayed for levels of plasma Hsp72, serum C-reactive protein, interleukin 6, tumor necrosis factor α, and regular biomedical parameters. We found that higher Hsp72 in plasma is associated with lower muscle mass, weaker grip strength, and slower walking speed, and may be a potential biomarker of sarcopenia in elderly people. This finding was supported by other results in the present study: (1) older age and shrinking body and lower hemoglobin levels, all of which characterize sarcopenia, were related to higher eHsp72 tertiles and (2) the ORs of the highest tertile of eHsp72 for the lowest tertiles of muscle mass, grip strength, and walking speed were 2.7, 2.6, and 1.8, respectively. These ORs were independent of age, sex, and the incidence of related diseases. Our results would reveal that eHsp72 in plasma is linked to sarcopenia factors and is a potential biomarker or predictor of sarcopenia.

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Acknowledgments

We are grateful to our elderly subjects in Kusatu-machi, Dr. Shoji Shinkai, Dr. Ryutaro Takahashi, and Dr. Hideki Ito, Tokyo Metropolitan Institute of Gerontology. We wish to acknowledge the contribution of the management of Kusatu-machi Health Center in Gunma and the Research Team for Social Participation and Health Promotion, Tokyo Metropolitan Institute of Gerontology. This study was supported by a Grant-in-Aid for the Scientist (1403 B: 21300261) of the Ministry of Education, Culture, Sports, Science and Technology of Japan.

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Authors and Affiliations

  1. Research Team for Social Participation and Health Promotion, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi, Tokyo, 173-0015, Japan

    Kishiko Ogawa

  2. Research Team for Promoting Independence of the Elderly, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi, Tokyo, 173-0015, Japan

    Hun-kyung Kim

  3. Research Team for Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi, Tokyo, 173-0015, Japan

    Takahiko Shimizu

  4. Department of Physical Education, Faculty of Sport Science, Nippon Sport Science University, 7-1-1 Fukasawa, Setagaya, Tokyo, 158-8508, Japan

    Sigeaki Abe

  5. Department of Nursing, Faculty of Nursing, Musashino University, 3-40-10 Sekimae Musashino-shi, Tokyo, 180-0014, Japan

    Yumi Shiga

  6. Department of Radiation Oncology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA

    Stuart K. Calderwood

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  1. Kishiko Ogawa
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  2. Hun-kyung Kim
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  3. Takahiko Shimizu
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  5. Yumi Shiga
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  6. Stuart K. Calderwood
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Correspondence to Kishiko Ogawa.

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Ogawa, K., Kim, Hk., Shimizu, T. et al. Plasma heat shock protein 72 as a biomarker of sarcopenia in elderly people. Cell Stress and Chaperones 17, 349–359 (2012). https://doi.org/10.1007/s12192-011-0310-6

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  • DOI: https://doi.org/10.1007/s12192-011-0310-6

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