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Long-term survival of donor bone marrow multipotent mesenchymal stromal cells implanted into the periosteum of patients with allogeneic graft failure

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Abstract

The present study involved three patients with graft failure following allogeneic hematopoietic stem cell transplantation (allo-HSCT). We obtained multipotent mesenchymal stromal cells (MSCs) from the original hematopoietic cell donors and implanted these cells in the periosteum to treat long-term bone marrow aplasia. The results showed that in all patients endogenous blood formation was recovered 2 weeks after MSC administration. Donor MSCs were found in recipient bone marrow three and 5 months following MSC implantation. Thus, our findings indicate that functional donor MSCs can persist in patient bone marrow.

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Acknowledgments

The study was supported by Grant 16-15-00102 from the “Russian Foundation for Humanities”. The materials maintained by Grant 15-04-02514 from the “Russian Fond of Fundamental Science” were used.

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Authors and Affiliations

  1. National Research Center for Hematology, Moscow, Russia

    L. A. Kuzmina, N. A. Petinati, N. V. Sats, N. J. Drize, N. V. Risinskaya, A. B. Sudarikov, V. A. Vasilieva, M. Y. Drokov, E. D. Michalzova, E. N. Parovichnikova & V. G. Savchenko

  2. Noviy Zikovsky pr, 4, Moscow, 125167, Russia

    N. J. Drize

Authors
  1. L. A. Kuzmina
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  2. N. A. Petinati
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  3. N. V. Sats
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  4. N. J. Drize
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  5. N. V. Risinskaya
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  6. A. B. Sudarikov
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  7. V. A. Vasilieva
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  8. M. Y. Drokov
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  9. E. D. Michalzova
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  10. E. N. Parovichnikova
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  11. V. G. Savchenko
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Corresponding author

Correspondence to N. J. Drize.

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The authors declare that they have no conflict of interest.

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Kuzmina, L.A., Petinati, N.A., Sats, N.V. et al. Long-term survival of donor bone marrow multipotent mesenchymal stromal cells implanted into the periosteum of patients with allogeneic graft failure. Int J Hematol 104, 403–407 (2016). https://doi.org/10.1007/s12185-016-2014-2

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  • DOI: https://doi.org/10.1007/s12185-016-2014-2

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