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Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) after treatment for Hodgkin’s lymphoma

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Abstract

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare central nervous system (CNS) disorder with distinct radiological features. However, CLIPEERS may mimic CNS lymphoma, and several cases in which CLIPPERS occurred premonitory to CNS lymphoma have been reported. We report a 31-year-old man presenting with progressive gait ataxia and the characteristic MRI features of CLIPPERS. He was diagnosed with stage II Hodgkin’s lymphoma at the age of 15, and we considered the possibility of newly emerged CNS lymphoma occurring in the immunosuppressive condition after the treatment of Hodgkin’s lymphoma. Histological findings showed no evidence of CNS lymphoma and the neurological symptoms were resolved by steroids. Although CLIPPERS developed in the reverse order in this case, CLIPPERS should be considered in different diagnosis for CNS lymphoma.

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Authors and Affiliations

  1. Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Kyoko Mashima, Shigeaki Suzuki, Toshihiko Shimizu, Satoshi Yamada & Norihiro Suzuki

  2. Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan

    Takehiko Mori & Shinichiro Okamoto

  3. Division of Diagnostic Pathology, Keio University School of Medicine, Tokyo, Japan

    Shigemichi Hirose

Authors
  1. Kyoko Mashima
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  2. Shigeaki Suzuki
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  3. Takehiko Mori
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  4. Toshihiko Shimizu
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  5. Satoshi Yamada
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  6. Shigemichi Hirose
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  7. Shinichiro Okamoto
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  8. Norihiro Suzuki
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Corresponding author

Correspondence to Shigeaki Suzuki.

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The authors have no conflict of interest to disclose.

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Mashima, K., Suzuki, S., Mori, T. et al. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) after treatment for Hodgkin’s lymphoma. Int J Hematol 102, 709–712 (2015). https://doi.org/10.1007/s12185-015-1850-9

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  • DOI: https://doi.org/10.1007/s12185-015-1850-9

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