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Differential expression of HOX genes upon activation of leukocyte sub-populations

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Abstract

The HOX genes are key determinants of cellular identity both in early development and in the renewal and differentiation of adult blood cells. Although a number of studies have examined the expression of individual HOX genes in defined blood cell lineages, we have undertaken a comprehensive analysis of HOX gene expression in resting and activated lymphocytic and monocytic subpopulations. This has revealed distinct patterns of expression between different cell types and resting and activated states. (Main category A: Erythrocytes, Leukocytes and Hematopoiesis, subcategory: 8: Lymphocytes).

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References

  1. Abramovich C, Humphries RK. Hox regulation of normal and leukemic hematopoietic stem cells. Curr Opin Hematol. 2005;12:210–6.

    Article  PubMed  CAS  Google Scholar 

  2. Biddison WE. Current protocols in cell bioloyg. In: Juan S Bonifacino, Mary Dasso, Joe B Harford, Jennifer Lippincott-Schwartz, Kenneth M. Yamada, editors 1998; Wiley.

  3. Carè A, Testa U, Bassani A, Tritarelli E, Montesoro E, Samoggia P, Cianetti L, Peschle C. Coordinate expression and proliferative role of HOXB genes in activated adult T lymphocytes. Mol Cell Biol. 1994;14:4872–7.

    PubMed  Google Scholar 

  4. Carroll SB. Homeotic genes and the evolution of arthropods and chordates. Nature. 1995;376:479–85.

    Article  PubMed  CAS  Google Scholar 

  5. Fuller JF, McAdara J, Yaron Y, Sakaguchi M, Fraser JK, Gasson JC. Characterization of HOX gene expression during myelopoiesis: role of HOXA5 in lineage commitment and maturation. Blood. 1999;93:3391–400.

    PubMed  CAS  Google Scholar 

  6. Grier DG, Thompson A, Kwasniewska A, McGonigle GJ, Halliday HL, Lappin TR. The pathophysiology of HOX genes and their role in cancer. J Pathol. 2005;205:154–71.

    Article  PubMed  CAS  Google Scholar 

  7. Lawrence HJ, Stage KM, Mathews CH, Detmer K, Scibienski R, MacKenzie M, Migliaccio E, Boncinelli E, Largman C. Expression of HOX C homeobox genes in lymphoid cells. Cell Growth Differ. 1993;4:665–9.

    PubMed  CAS  Google Scholar 

  8. Lawrence HJ, Helgason CD, Sauvageau G, Fong S, Izon DJ, Humphries RK, Largman C. Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis. Blood. 1997;89:1922–30.

    PubMed  CAS  Google Scholar 

  9. Martinez-Delgado B, Melendez B, Cuadros M, Alvarez J, Castrillo JM, Ruiz De La Parte A, Mollejo M, Bellas C, Diaz R, Lombardia L, Al-Shahrour F, Dominguez O, Cascon A, Robledo M, Rivas C, Benitez J. Expression profiling of T cell lymphomas differentiates peripheral and lymphoblastic lymphomas and defines survival related genes. Clin Cancer Res. 2004;10:4971–82.

    Article  PubMed  CAS  Google Scholar 

  10. Morgan R. Young blood: Hox genes and haematopoietic stem cells. Trends Genet. 2002;18:345–6.

    Article  CAS  Google Scholar 

  11. Morgan R, Maconas Pirard P, Shears L, Sohal J, Pettengell R, Pandha HS. Antagonism of HOX/PBX dimer formation blocks the in vivo proliferation of melanoma. Cancer Res. 2007; 67:5806-13.

    Article  PubMed  CAS  Google Scholar 

  12. Shen W, Chrobak D, Krishnan K, Lawrence HJ, Largman C. HOXB6 protein is bound to CREB-binding protein and represses globin expression in a DNA binding-dependent, PBX interaction-independent process. J Biol Chem. 2004;279:39895–904.

    Article  PubMed  CAS  Google Scholar 

  13. Shimamoto T, Ohyashiki K, Toyama K, Takeshita K. Homeobox genes in hematopoiesis and leukemogenesis. Int J Hematol. 1998;67:339–50.

    Article  PubMed  CAS  Google Scholar 

  14. Taghon T, Stolz F, De Smedt M, Cnockaert M, Verhasselt B, Plum J, Leclercq G. HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor. Blood. 2002;99:1197–1204.

    Article  PubMed  CAS  Google Scholar 

  15. Takeshita K, Bollekens JA, Hijiya N, Ratajczak M, Ruddle FH, Gewirtz AM. A homeobox gene of the Antennapedia class is required for human adult erythropoiesis. Proc Natl Acad Sci U S A. 1993;90:3535–8.

    Article  PubMed  CAS  Google Scholar 

  16. Wang GG, Calvo KR, Pasillas MP, Sykes DB, Hacker H, Kamps MP. Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8. Nat Methods. 2006;3:287–93.

    Article  PubMed  CAS  Google Scholar 

  17. Yao MW, Lim H, Schust DJ, Choe SE, Farago A, Ding Y, Michaud S, Church GM, Maas RL. Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. Mol Endocrinol. 2003;17:610–27.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Postgraduate Medical School, University of Surrey, Guildford, Surrey, GU2 7WG, UK

    Richard Morgan

  2. School of Life Science, Kingston University, Penrhyn Road, Kingston upon Thames, KT1 2EE, UK

    Karen Whiting

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  1. Richard Morgan
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  2. Karen Whiting
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Correspondence to Richard Morgan.

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Morgan, R., Whiting, K. Differential expression of HOX genes upon activation of leukocyte sub-populations. Int J Hematol 87, 246–249 (2008). https://doi.org/10.1007/s12185-008-0057-8

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  • DOI: https://doi.org/10.1007/s12185-008-0057-8

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