Original Article

International Journal of Hematology

, Volume 87, Issue 3, pp 246-249

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Differential expression of HOX genes upon activation of leukocyte sub-populations

  • Richard MorganAffiliated withPostgraduate Medical School, University of Surrey Email author 
  • , Karen WhitingAffiliated withSchool of Life Science, Kingston University


The HOX genes are key determinants of cellular identity both in early development and in the renewal and differentiation of adult blood cells. Although a number of studies have examined the expression of individual HOX genes in defined blood cell lineages, we have undertaken a comprehensive analysis of HOX gene expression in resting and activated lymphocytic and monocytic subpopulations. This has revealed distinct patterns of expression between different cell types and resting and activated states. (Main category A: Erythrocytes, Leukocytes and Hematopoiesis, subcategory: 8: Lymphocytes).


HOX T-lymphocytes B-lymphocytes Monocytes Activation