Does Exposure to Stressors Predict Changes in Physiological Dysregulation?
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The allostatic load framework implies that cumulative exposure to stressors results in multi-system physiological dysregulation.
The purpose of this study was to investigate the effect of stress burden on subsequent changes (2000–2006) in physiological dysregulation.
Data came from a population-based cohort study in Taiwan (n = 521, aged 54+ in 2000, re-examined in 2006). Measures of stressful events and chronic strain were based on questions asked in 1996, 1999, and 2000. A measure of trauma was based on exposure to the 1999 earthquake. Dysregulation was based on 17 biomarkers (e.g., metabolic, inflammatory, neuroendocrine).
There were some small effects among men: chronic strain was associated with subsequent increases in dysregulation (standardized β = 0.08, 95 % CI = 0.01 to 0.20), particularly inflammation; life events were also associated with increased inflammation (β = 0.10, CI = 0.01 to 0.26). There were no significant effects in women.
We found weak evidence that stress burden is associated with changes in dysregulation.
- McEwen BS, Stellar E. Stress and the individual. Mechanisms leading to disease. Arch Intern Med. 1993; 153(18): 2093-2101. CrossRef
- McEwen BS. Sex, stress and the hippocampus: Allostasis, allostatic load and the aging process. Neurobiol Aging. 2002; 23(5): 921-939. CrossRef
- Juster RP, McEwen BS, Lupien SJ. Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci Biobehav Rev. 2010; 35(1): 2-16. CrossRef
- Clark MS, Bond MJ, Hecker JR. Environmental stress, psychological stress and allostatic load. Psychol Health Med. 2007; 12(1): 18-30. CrossRef
- Glei DA, Goldman N, Chuang YL, Weinstein M. Do chronic stressors lead to physiological dysregulation? Testing the theory of allostatic load. Psychosom Med. 2007; 69(8): 769-776. CrossRef
- Evans GW. A multimethodological analysis of cumulative risk and allostatic load among rural children. Dev Psychol. 2003; 39(5): 924-933. CrossRef
- Gustafsson PE, Janlert U, Theorell T, Westerlund H, Hammarstrom A. Social and material adversity from adolescence to adulthood and allostatic load in middle-aged women and men: Results from the Northern Swedish Cohort. Ann Behav Med. 2011. doi:10.1007/s12160-011-9309-6.
- Roepke SK, Mausbach BT, Patterson TL, et al. Effects of Alzheimer caregiving on allostatic load. J Health Psychol. 2011; 16(1): 58-69. doi:10.1177/1359105310369188. CrossRef
- Mair CA, Cutchin MP, Kristen PM. Allostatic load in an environmental riskscape: The role of stressors and gender. Health Place. 2011; 17(4): 978-987. doi:10.1016/j.healthplace.2011.03.009. CrossRef
- Gallo LC, Jimenez JA, Shivpuri S, Espinosa de los Monteros K, Mills PJ. Domains of chronic stress, lifestyle factors, and allostatic load in middle-aged Mexican-American women. Ann Behav Med. 2011; 41(1): 21-31. CrossRef
- Goldman N, Glei DA, Seplaki C, Liu IW, Weinstein M. Perceived stress and physiological dysregulation in older adults. Stress. 2005; 8(2): 95-105. CrossRef
- Pearlin LI. The sociological study of stress. J Health Soc Behav. 1989; 30(3): 241-256. CrossRef
- Cohen S, Wills TA. Stress, social support, and the buffering hypothesis. Psychol Bull. 1985; 98(2): 310-357. CrossRef
- Wheaton B. Models for the stress-buffering functions of coping resources. J Health Soc Behav. 1985; 26(4): 352-364. CrossRef
- Thoits PA. Stress and health: Major findings and policy implications. J Health Soc Behav. 2010; 51(Suppl): S41-S53. doi:10.1177/0022146510383499. CrossRef
- Chang M, Lin H, Chuang Y, et al. Social Environment and Biomarkers of Aging Study (SEBAS) in Taiwan, 2000 and 2006: Main documentation for SEBAS longitudinal public use data (released 2012). Ann Arbor, MI: Inter-university Consortium for Political and Social Research [distributor]; 2012; No. ICPSR03792-v5.
- Chang M, Glei D, Goldman N, Weinstein M. The Taiwan biomarker project. In: Weinstein M, Vaupel JW, Wachter KW, eds. Biosocial Surveys. Committee on Advances in Collecting and Utilizing Biological Indicators and Genetic Information in Social Science Surveys, Committee on Population, Division of Behavioral and Social Sciences and Education. Washington, DC: The National Academies Press; 2007: 3-1–3-16.
- Gruenewald TL, Karlamangla AS, Hu P, et al. History of socioeconomic disadvantage and allostatic load in later life. Soc Sci Med. 2012; 74(1): 75-83. doi:10.1016/j.socscimed.2011.09.037. CrossRef
- Glei DA, Goldman N, Lin Y, Weinstein M. Relaxation practice and physiologic regulation in a national sample of older Taiwanese. Journal of Alternative and Complementary Medicine. 2012; 18(7): 653-661. CrossRef
- Cornwell EY, Waite LJ. Measuring social isolation among older adults using multiple indicators from the NSHAP study. J Gerontol B Psychol Sci Soc Sci. 2009; 64(Suppl 1): i38-i46. doi:10.1093/geronb/gbp037. CrossRef
- Pearlin LI, Lieberman MA, Menaghan EG, Mullan JT. The stress process. J Health Soc Behav. 1981; 22(4): 337-356. CrossRef
- McDade TW. Challenges and opportunities for integrative health research in the context of culture: A commentary on Gersten. Soc Sci Med. 2008; 66: 520-524. CrossRef
- Bonanno GA. Loss, trauma, and human resilience: Have we underestimated the human capacity to thrive after extremely aversive events? Am Psychol. 2004; 59(1): 20-28. doi:10.1037/0003-066X.59.1.20. CrossRef
- Seeman TE, Singer BH, Rowe JW, Horwitz RI, McEwen BS. Price of adaptation–allostatic load and its health consequences. MacArthur Studies of Successful Aging. Arch Intern Med. 1997; 157(19): 2259-2268. CrossRef
- Does Exposure to Stressors Predict Changes in Physiological Dysregulation?
Annals of Behavioral Medicine
Volume 46, Issue 1 , pp 121-126
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Psychological stress
- Life challenges
- Allostatic load
- Physiological dysregulation
- Biological markers
- Industry Sectors
- Author Affiliations
- 1. Center for Population and Health, Georgetown University, Washington, DC, USA
- 4. 5985 San Aleso Court, Santa Rosa, CA, 95409-3912, USA
- 2. Office of Population Research, Princeton University, Princeton, NJ, USA
- 3. Population and Health Research Center, Bureau of Health Promotion, Department of Health, Taipei, Taiwan, Republic of China