Does Exposure to Stressors Predict Changes in Physiological Dysregulation?
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The allostatic load framework implies that cumulative exposure to stressors results in multi-system physiological dysregulation.
The purpose of this study was to investigate the effect of stress burden on subsequent changes (2000–2006) in physiological dysregulation.
Data came from a population-based cohort study in Taiwan (n = 521, aged 54+ in 2000, re-examined in 2006). Measures of stressful events and chronic strain were based on questions asked in 1996, 1999, and 2000. A measure of trauma was based on exposure to the 1999 earthquake. Dysregulation was based on 17 biomarkers (e.g., metabolic, inflammatory, neuroendocrine).
There were some small effects among men: chronic strain was associated with subsequent increases in dysregulation (standardized β = 0.08, 95 % CI = 0.01 to 0.20), particularly inflammation; life events were also associated with increased inflammation (β = 0.10, CI = 0.01 to 0.26). There were no significant effects in women.
We found weak evidence that stress burden is associated with changes in dysregulation.
- Does Exposure to Stressors Predict Changes in Physiological Dysregulation?
Annals of Behavioral Medicine
Volume 46, Issue 1 , pp 121-126
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Psychological stress
- Life challenges
- Allostatic load
- Physiological dysregulation
- Biological markers
- Industry Sectors
- Author Affiliations
- 1. Center for Population and Health, Georgetown University, Washington, DC, USA
- 4. 5985 San Aleso Court, Santa Rosa, CA, 95409-3912, USA
- 2. Office of Population Research, Princeton University, Princeton, NJ, USA
- 3. Population and Health Research Center, Bureau of Health Promotion, Department of Health, Taipei, Taiwan, Republic of China