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Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules

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Journal of Chemical Biology

Abstract

This review describes the progress that has been made in understanding the PI3-K-PKB-mTOR signalling pathway by using small molecules as pharmacological probes. It briefly covers the structural characteristics, regulation of and downstream effects of several key regulators of PI3-K-PKB-mTOR signalling, then highlights the use of small molecules (by structural type) to selectively modulate specific components of the pathway.

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Acknowledgements

We thank the UK Engineering and Physical Sciences Research Council (EPSRC) for funding (RMG).

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  1. Department of Chemistry, University College London, London, WC1H 0AJ, UK

    Richard M. Gunn & Helen C. Hailes

  2. Chemical Biology Centre, Imperial College London, Exhibition Road, London, SW7 2AZ, UK

    Richard M. Gunn

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Correspondence to Richard M. Gunn.

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Gunn, R.M., Hailes, H.C. Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules. J Chem Biol 1, 49–62 (2008). https://doi.org/10.1007/s12154-008-0008-0

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  • DOI: https://doi.org/10.1007/s12154-008-0008-0

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