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Effect of radioactive iodine therapy on carotid intima media thickness in patients with hyperthyroidism

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Abstract

Objective

The aim of this study was to evaluate the carotid intima media thickness (IMT) in patients with thyrotoxicosis who received radioactive iodine (RAI) treatment.

Methods

This study was planned to be conducted with two different groups of people. There were 87 patients in the patient group and 98 controls. Participants were evaluated for atherosclerosis risk factors. Mean carotid IMT was measured from three consecutive traces at the common carotid artery bifurcation.

Results

The mean carotid IMT was 0.81 ± 0.20 in patient group and this was higher than the controls (0.68 ± 0.19) (p < 0.01). IM thickening was positively correlated with the applied RAI dose levels in the treatment group (p = 0.029). In patients with only HT, the data of the two groups showed a significant difference, with the average IMT being higher in the patient group than that of the control group (p: 0.011).

Conclusion

RAI used in the treatment of thyrotoxicosis increases the IMT of carotid artery independent of age and sex. This treatment yields better results with higher doses, and this effect is more marked in patients with HT. Hence, we believe that it is necessary to calculate the dose properly for hyperthyroid cases in which treatment with RAI is planned. In particular, the patients with HT need to be treated with the minimum possible dose. Further, carotid arteries should be evaluated with US following RAI treatment.

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Authors and Affiliations

  1. Department of Radiology, Dumlupinar University Faculty of Medicine, Kutahya, Turkey

    Bekir Şanal, Mehmet Korkmaz & Fatma Can

  2. Department of Nuclear Medicine, Dumlupinar University Faculty of Medicine, Kutahya, Turkey

    İlknur Işık

  3. Department of Otorhinolaryngology, Head and Neck Surgery, Dumlupinar University Faculty of Medicine, Kutahya, Turkey

    Cüneyt Kucur

  4. Department of Internal Medicine, Dumlupinar University Faculty of Medicine, Kutahya, Turkey

    Türkan Paşalı Kilit & Cüneyt Kahraman

  5. Department of Radiology, Kocatepe University Faculty of Medicine, Afyonkarahisar, Turkey

    Emre Kaçar

  6. Department of Histology and Embryology, Dumlupinar University Faculty of Medicine, Kutahya, Turkey

    Ahmet Koçak

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  1. Bekir Şanal
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Correspondence to Bekir Şanal.

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Şanal, B., Işık, İ., Korkmaz, M. et al. Effect of radioactive iodine therapy on carotid intima media thickness in patients with hyperthyroidism. Ann Nucl Med 30, 75–80 (2016). https://doi.org/10.1007/s12149-015-1033-z

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  • DOI: https://doi.org/10.1007/s12149-015-1033-z

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