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Carbon-14 urea breath test: does it work in patients with partial gastric resection?

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Abstract

Objective

The diagnostic value of Carbon-14 urea breath test (C-14 UBT) in the detection of Helicobacter pylori (H. pylori) infection in non-operated patients has been proved. However, the efficacy of C-14 UBT in patients with partial gastric resection (PGR) has not been evaluated yet. Herein, the results of the C-14 UBT and H. pylori stool antigen test (HpSAT) in this patient group were compared with the endoscopic findings.

Methods

Multi-breath samples C-14 UBT and HpSAT were performed in all patients on the same day. Histology was used as a gold standard for testing C-14 UBT and HpSAT diagnostic efficacies.

Results

30 patients (mean age: 54.6 ± 11 year) with PGR were included. The sensitivity and specificity of standard C-14 UBT were 29 and 100 %, respectively. When breath samples were collected at 20th min, and >35 CPM was selected as radioactivity threshold, the sensitivity raised to 86 % without any loss of specificity. The specificity and sensitivity of the HpSAT were 71 and 96 %, respectively.

Conclusions

The sensitivity of the standard C-14 UBT was very poor for patients with PGR, and results of HpSAT were superior in this population. Certain modifications are needed if C-14 UBT is to be used in PGR patients.

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Conflict of interest

All the authors state that there were no conflicts of interests when the manuscript was written.

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Marmara University School of Medicine, Istanbul, Turkey

    Fuat Dede, Halil Turgut Turoglu & Sabahat Inanir

  2. Nuclear Medicine Clinic, Kocaeli State Hospital, Kocaeli, Turkey

    Hüseyin Civen

  3. Department of Medical Oncology, Marmara University School of Medicine, Istanbul, Turkey

    Faysal Dane & Serdar Turhal

  4. Internal Medicine Clinic, Kartal Dr. Lutfi Kirdar Research and Training Hospital, Istanbul, Turkey

    Mehmet Aliustaoglu

  5. Nukleer Tip Anabilim Dali, S.B. Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi, -1 kat A1 Blok Fevzi Cakmak Mahallesi Mimar Sinan Caddesi No:41 Ustkaynarca, Pendik, Istanbul, Turkey

    Fuat Dede

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  1. Fuat Dede
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  2. Hüseyin Civen
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Correspondence to Fuat Dede.

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Dede, F., Civen, H., Dane, F. et al. Carbon-14 urea breath test: does it work in patients with partial gastric resection?. Ann Nucl Med 29, 786–791 (2015). https://doi.org/10.1007/s12149-015-1005-3

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  • DOI: https://doi.org/10.1007/s12149-015-1005-3

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