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Comparison of estimated human dose of 68Ga-MAA with 99mTc-MAA based on rat data

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Abstract

Objective

99mTc macroaggregated albumin (99mTc-MAA) that had been used as a perfusion agent has been evaluated. In this study, we tried to estimate human absorbed dose of 68Ga-MAA via commercially available kit from Pars-Isotopes, based on biodistribution data in wild-type rats, and compare our estimation with the available absorbed dose data from 99mTc-MAA.

Methods

For biodistribution of 68Ga-MAA, three rats were sacrificed at each selected times after injection (15, 30, 45, 60, and 120 min) and the percentage of injected dose per gram of each organ was measured by direct counting from rats data from 11 harvested organs. The medical internal radiation dose formulation was applied to extrapolate from rats to human and to project the absorbed radiation dose for various organs in humans.

Results

The biodistribution data for 68Ga-MAA showed that the most of the activity was taken up by the lung (more than 97 %) in no time. Our dose prediction shows that a 185-MBq injection of 68Ga-MAA into humans might result in an estimated absorbed dose of 4.31 mGy in the whole body. The highest absorbed doses are observed in the adrenals, spleen, pancreas, and red marrow with 0.36, 0.34, 0.26, and 0.19 mGy, respectively.

Conclusion

Since the 99mTc-MAA remains longer than 68Ga-MAA in the lung and 68Ga-MAA has good image qualities and results in lower amounts of dose delivery to the critical organs such as gonads, red marrow, and adrenals, the use of 68Ga-MAA is recommended.

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Acknowledgments

This work was supported by the Nuclear Science and Technology Research Institute (NSTRI).

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Authors and Affiliations

  1. Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), P. O. Box: 11365-3486, Tehran, Iran

    Saeed Shanehsazzadeh, Hassan Yousefnia & Amir Reza Jalilian

  2. Department of Medical Physics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Afsaneh Lahooti

  3. Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Parham Geramifar

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  1. Saeed Shanehsazzadeh
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Correspondence to Saeed Shanehsazzadeh.

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Shanehsazzadeh, S., Lahooti, A., Yousefnia, H. et al. Comparison of estimated human dose of 68Ga-MAA with 99mTc-MAA based on rat data. Ann Nucl Med 29, 745–753 (2015). https://doi.org/10.1007/s12149-015-0997-z

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  • DOI: https://doi.org/10.1007/s12149-015-0997-z

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