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Prognostic value of semi-quantitative tumor uptake on Tc-99m sestamibi breast-specific gamma imaging in invasive ductal breast cancer

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Abstract

Objectives

This study investigated the prognostic value of preoperative breast-specific gamma imaging (BSGI) uptake measured by a semi-quantitative method in invasive ductal carcinoma (IDC).

Methods

One hundred and sixty-two women with IDC who underwent preoperative BSGI were retrospectively enrolled. The tumor-to-normal tissue ratio (TNR) was measured on BSGI and correlated with histologic prognostic factors. The prognostic impact of TNR was tested with regard to progression-free survival (PFS) and compared with established prognostic factors.

Results

High TNR was significantly correlated with tumor size >2 cm (p < 0.001), high nuclear grade (p = 0.04), high histologic grade (p = 0.01), axillary node positivity (p = 0.04), ER negativity (p = 0.03), HER2 positivity (p = 0.01), and high MIB-1 index (p = 0.001). Among 162 patients, 14 experienced recurrence during mean follow-up time of 34.7 ± 14.9 months. In Kaplan–Meier survival analyses, high TNR (p < 0.001), high nuclear grade (p = 0.02), high histologic grade (p = 0.007), ER/PR negativity (p = 0.003 and p < 0.001, respectively), HER2 positivity (p = 0.01), triple negativity (p = 0.02), and high MIB-1 index (p = 0.02) showed a significant relationship with poor prognosis. Among them, high TNR was an independent poor prognostic factor in a multivariate regression analysis (p = 0.01).

Conclusions

High BSGI uptake measured by a semi-quantitative method was correlated with diverse poor histologic prognostic factors and was an independent poor prognostic factor in invasive ductal cancer.

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Acknowledgments

This research was supported by the Basic Science Research Program and the Bio and Medical Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (2012R1A1A1012913 and 2012M3A9B6055379).

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Authors and Affiliations

  1. Department of Nuclear Medicine, Ewha Womans University School of Medicine, 911-1 Mok-Dong, Yangchun-ku, Seoul, 158-710, Republic of Korea

    Hai-Jeon Yoon & Bom Sahn Kim

  2. Clinical Research Institute, Ewha Womans University, Seoul, Republic of Korea

    Yemi Kim & Bom Sahn Kim

  3. National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea

    Kyu-Tae Chang & Bom Sahn Kim

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  1. Hai-Jeon Yoon
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  2. Yemi Kim
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Correspondence to Bom Sahn Kim.

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Yoon, HJ., Kim, Y., Chang, KT. et al. Prognostic value of semi-quantitative tumor uptake on Tc-99m sestamibi breast-specific gamma imaging in invasive ductal breast cancer. Ann Nucl Med 29, 553–560 (2015). https://doi.org/10.1007/s12149-015-0977-3

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  • DOI: https://doi.org/10.1007/s12149-015-0977-3

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