Abstract
Electrospray ionization IMS coupled to quadrupole mass spectrometry was used to calculate the reduced ion mobilities of aspartame, cortisone, betamethasone, butylparaben, propylparaben and vanillin, a set of organic compounds used as drugs or food additives using 2,6-ditert-butylpyridine (DTBP) as a chemical standard. The K0’S of these compounds in the literature are either unavailable or unreliable. The importance of using chemical standards to calibrate the ion mobility scale and the use of correct experimental temperatures to calculate ion mobilities are stressed.
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References
Eiceman GA, Kelly K, Nazarov EG (2002) Nitric oxide as a reagent gas in ion mobility spectrometry. Int J Ion Mobil Spectrom 5:22–30
Eiceman GA, Nazarov EG, Stone JA (2003) Chemical standards in ion mobility spectrometry. Anal Chim Acta 493:185–194
Ewing RG, Atkinson DA, Eiceman GA, Ewing GJ (2001) A critical review of ion mobility spectrometry for the detection of explosives and explosive related compounds. Talanta 54:515–529
Fernández-Maestre R, Hill Jr. HH (2009) Ion mobility spectrometry for the rapid analysis of overthe-counter drugs and beverages. Int J Ion Mob Spectrom 12:91–102
Fernandez-Maestre R, Wu C, Hill HH (2015a) Separation of Asparagine, Valine and Tetraethylammonium ions Overlapping in an Ion Mobility Spectrometer by clustering with Methanol introduced as a modifier in the Buffer Gas. Anal Meth 7:863–869
Fernandez-Maestre R, Meza-Morelos D, Hill HH (2015b) Mobilities of amino acid adducts with modifiers in the buffer gas of an ion mobility spectrometer depended on modifier size and modifier–amino acid interaction energy. Int J Mass Spectrom 380:21–25
Fernandez‐Maestre R, Meza‐Morelos D, Wu C (2016) Deprotonation effect of tetrahydrofuran‐2‐ carbonitrile buffer gas dopant in ion mobility spectrometry. Rapid Comm Mass Spectrom 30:1332–1338
Jones D, Brenton AG, Games DE, Brittain AH, Taylor S, Kennedy D, Smith P (1993) Ion mobility spectrometry as a detection technique for the separation sciences. Rap Comm Mass Spectrom 7:561–566
Kim SH, Betty KR, Karasek FW (1978) Plasma chromatography of benzene with mass identified mobility spectra. Anal Chem 50:1784–1788
Lokhnauth JK, Snow NH (2005) Determination of parabens in pharmaceutical formulations by solid-phase microextraction-ion mobility spectrometry. Anal Chem 77:5938–5946
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Fernández-Maestre, R. Reduced ion mobilities of aspartame, cortisone, betamethasone, butylparaben, propylparaben and vanillin. Int. J. Ion Mobil. Spec. 20, 11–13 (2017). https://doi.org/10.1007/s12127-017-0216-9
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DOI: https://doi.org/10.1007/s12127-017-0216-9