Skip to main content

Advertisement

SpringerLink
Log in

Hybrid Intercalated Duct Lesion of the Parotid: Diagnostic Challenges of a Recently Described Entity with Fine Needle Aspiration Findings

  • Case Report
  • Published:
Head and Neck Pathology Aims and scope Submit manuscript

Abstract

Intercalated duct lesions (IDL) of the salivary glands are recently described, and encompass both hyperplasia and benign neoplasms that remain incompletely understood. IDLs have been linked to various benign and low-grade malignant salivary gland neoplasms. We herein present a case of a 77 year old woman with an IDL of the parotid composed of both a hyperplastic and an adenomatous component and report, for the first time, the fine needle aspiration findings of such a lesion. This case illustrates the morphologic spectrum of an IDL, as well as challenges in rendering an accurate cytological and histologic diagnosis. The potential diagnostic pitfalls presented by the hybrid pattern of this lesion are also discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Weinreb I, Seethala RR, Hunt JL, Chetty R, Dardick I, Perez-Ordonez B. Intercalated duct lesions of salivary gland: a morphologic spectrum from hyperplasia to adenoma. Am J Surg Pathol. 2009;33(9):1322–9. doi:10.1097/PAS.0b013e3181a55c15.

    Article  PubMed  Google Scholar 

  2. Naunheim MR, Lin HW, Faquin WC, Lin DT. Intercalated duct lesion of the parotid. Head Neck Pathol. 2012;6(3):373–6. doi:10.1007/s12105-012-0329-8.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Chetty R. Intercalated duct hyperplasia: possible relationship to epithelial-myoepithelial carcinoma and hybrid tumours of salivary gland. Histopathology. 2000;37(3):260–3.

    Article  CAS  PubMed  Google Scholar 

  4. Di Palma S. Epithelial-myoepithelial carcinoma with co-existing multifocal intercalated duct hyperplasia of the parotid gland. Histopathology. 1994;25(5):494–6.

    Article  PubMed  Google Scholar 

  5. Yu GY, Donath K. Adenomatous ductal proliferation of the salivary gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91(2):215–21. doi:10.1067/moe.2001.110419.

    Article  CAS  PubMed  Google Scholar 

  6. Weinreb I, Simpson RH, Skalova A, Perez-Ordonez B, Dardick I, Chetty R, et al. Ductal adenomas of salivary gland showing features of striated duct differentiation (‘striated duct adenoma’): a report of six cases. Histopathology. 2010;57(5):707–15. doi:10.1111/j.1365-2559.2010.03682.x.

    Article  PubMed  Google Scholar 

  7. Montalli VA, Martinez E, Tincani A, Martins A, Abreu Mdo C, Neves C, et al. Tubular variant of basal cell adenoma shares immunophenotypical features with normal intercalated ducts and is closely related to intercalated duct lesions of salivary gland. Histopathology. 2014;64(6):880–9. doi:10.1111/his.12339.

    Article  PubMed  Google Scholar 

  8. Martins C, Fonseca I, Roque L, Pereira T, Ribeiro C, Bullerdiek J, et al. PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry. Mod Pathol. 2005;18(8):1048–55. doi:10.1038/modpathol.3800386.

    Article  CAS  PubMed  Google Scholar 

  9. Rotellini M, Palomba A, Baroni G, Franchi A. Diagnostic utility of PLAG1 immunohistochemical determination in salivary gland tumors. Appl Immunohistochem Mol Morphol. 2014;22(5):390–4. doi:10.1097/PAI.0b013e3182936ea7.

    Article  CAS  PubMed  Google Scholar 

  10. Brill LB 2nd, Kanner WA, Fehr A, Andren Y, Moskaluk CA, Loning T, et al. Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms. Mod Pathol. 2011;24(9):1169–76. doi:10.1038/modpathol.2011.86.

    Article  CAS  PubMed  Google Scholar 

  11. West RB, Kong C, Clarke N, Gilks T, Lipsick JS, Cao H, et al. MYB expression and translocation in adenoid cystic carcinomas and other salivary gland tumors with clinicopathologic correlation. Am J Surg Pathol. 2011;35(1):92–9. doi:10.1097/PAS.0b013e3182002777.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Mandel SJ, Mandel L. Radioactive iodine and the salivary glands. Thyroid. 2003;13(3):265–71. doi:10.1089/105072503321582060.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, National University Health System, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore

    Yingting Mok, Yin Huei Pang, Ming Teh & Fredrik Petersson

Authors
  1. Yingting Mok
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yin Huei Pang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ming Teh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fredrik Petersson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fredrik Petersson.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mok, Y., Pang, Y.H., Teh, M. et al. Hybrid Intercalated Duct Lesion of the Parotid: Diagnostic Challenges of a Recently Described Entity with Fine Needle Aspiration Findings. Head and Neck Pathol 10, 269–274 (2016). https://doi.org/10.1007/s12105-015-0663-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12105-015-0663-8

Keywords

Search

Navigation