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Squamous Cell Carcinoma of Parotid Gland Associated with Concurrent Lymphoepithelial Cysts and Lymphoepithelial Lesion: Case Report and Proposed Histogenesis

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Abstract

Lymphoepithelial cyst and lymphoepithelial lesion have similar histologic features and an affinity for the parotid gland. Though considered as different entities, both conditions arise from heterotopic salivary epithelial rests or inclusions in intra- or peri-parotid lymph nodes. We present a case of squamous cell carcinoma of parotid gland associated with concurrent lymphoepithelial cyst and lymphoepithelial lesion in a patient who was not infected with human immunodeficiency virus. We propose that lymphoepithelial cyst and lymphoepithelial lesion have a similar histogenesis.

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References

  1. Uccini S, D’Offizi G, Angelici A, Prozzo A, Riva E, Antonelli G, et al. Cystic lymphoepithelial lesions of the parotid gland in HIV-1 infection. AIDS Patient Care STDS. 2000;14(3):143–7. doi:10.1089/108729100317920.

    Article  CAS  PubMed  Google Scholar 

  2. Godwin JT. Benign lymphoepithelial lesion of the parotid gland adenolymphoma, chronic inflammation, lymphoepithelioma, lymphocytic tumor, mikulicz disease. Cancer. 1952;5(6):1089–103.

    Article  CAS  PubMed  Google Scholar 

  3. Bernier JL, Bhaskar SN. Lymphoepithelial lesions of salivary glands; histogenesis and classification based on 186 cases. Cancer. 1958;11(6):1156–79.

    Article  CAS  PubMed  Google Scholar 

  4. Fujibayashi T, Itoh H. Lymphoepithelial (so-called branchial) cyst within the parotid gland. Report of a case and review of the literature. Int J Oral Surg. 1981;10(4):283–92.

    Article  CAS  PubMed  Google Scholar 

  5. Azzopardi JG, Evans DJ. Malignant lymphoma of parotid associated with mikulicz disease (benign lymphoepithelial lesion). J Clin Pathol. 1971;24(8):744–52.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Sato K. Malignant lymphoma in the head and neck associated with benign lymphoepithelial lesion of the parotid gland. Auris Nasus Larynx. 2002;29:209–14.

    Article  PubMed  Google Scholar 

  7. Gravanis MB, Giansanti JS. Malignant histopathologic counterpart of the benign lymphoepithelial lesion. Cancer. 1970;26(6):1332–42.

    Article  CAS  PubMed  Google Scholar 

  8. Hilderman WC, Gordon JS, Large HL Jr, Carroll CF Jr. Malignant lymphoepithelial lesion with carcinomatous component apparently arising in parotid gland. A malignant counterpart of benign lymphoepithelial lesion? Cancer. 1962;15:606–10.

    Article  CAS  PubMed  Google Scholar 

  9. Camilleri AC, Lloyd RE. Lymphoepithelial cyst of the parotid gland. Br J Oral Maxillofac Surg. 1990;28(5):329–32.

    Article  CAS  PubMed  Google Scholar 

  10. Kojima M, Nakamura N, Matsuda H, Kaba S, Itoh H, Masawa N. HIV-unrelated benign lymphoepithelial cyst of the parotid glands containing lymphoepithelial lesion—like structures: a report of 3 cases. Int J Surg Pathol. 2009;17(6):421–5. doi:10.1177/1066896908328575.

    Article  PubMed  Google Scholar 

  11. Wu L, Cheng J, Maruyama S, Yamazaki M, Tsuneki M, Lu Y, et al. Lymphoepithelial cyst of the parotid gland: its possible histopathogenesis based on clinicopathologic analysis of 64 cases. Hum Pathol. 2009;40(5):683–92. doi:10.1016/j.humpath.2008.10.012.

    Article  PubMed  Google Scholar 

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Acknowledgments

We thank Dr. Adel El-Naggar for providing Figure 2. JHZ is supported by NIH Grant T32CA163185.

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Correspondence to Jane H. Zhou.

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Zhou, J.H., Christopher Holsinger, F. Squamous Cell Carcinoma of Parotid Gland Associated with Concurrent Lymphoepithelial Cysts and Lymphoepithelial Lesion: Case Report and Proposed Histogenesis. Head and Neck Pathol 9, 305–308 (2015). https://doi.org/10.1007/s12105-014-0571-3

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  • DOI: https://doi.org/10.1007/s12105-014-0571-3

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