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Mammary Analogue Secretory Carcinoma of Salivary Gland Origin: An Update and Expanded Morphologic and Immunohistochemical Spectrum of Recently Described Entity

  • Invited Review: An Update on Salivary Gland Pathology
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Abstract

Mammary analogue secretory carcinoma of salivary gland origin (MASC) is a recently described tumor with ETV6 translocation. Akin to secretory breast cancer, MASC expresses S-100 protein, mammaglobin, vimentin, and harbors a t(12;15) (p13;q25) translocation which leads to ETV6-NTRK3 fusion product. Histologically, MASC displays a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogeneous or bubbly secretions. Colloid-like secretory material stains positive for periodic acid-Schiff (PAS) with and without diastase and for Alcian blue. The cells of MASC are devoid of PAS-positive secretory zymogen granules. These features help to exclude the most important differential diagnostic considerations, namely acinic cell carcinoma, low-grade cribriform cystadenocarcinoma, cystadenocarcinoma (not otherwise specified), and low-grade mucoepidermoid carcinoma. To date the presence of the ETV6-NTRK3 fusion gene has not been demonstrated in any other salivary gland tumor than MASC. It is likely that MASC is more common than currently recognized and with further studies, the clinical need for molecular studies of the ETV6-NTRK3 fusion may diminish. However, molecular testing is recommended at this time to arrive at the diagnosis of MASC.

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References

  1. Barnes L, Eveson J, Reichart P, Sidransky D, editors. Pathology and genetics of head and neck tumours. World Health Organization classification of tumours. Lyon: IARC Press; 2005.

    Google Scholar 

  2. Gnepp DR, Henley JD, Simpson RHW, Eveson J. Salivary and Lacrimal glands. In: Gnepp DR, editors. Diagnostic surgical pathology of the head and neck. 2nd ed. Philadelphia: Saunders Elsevier, pp. 413–562.

  3. Hunt JL. An update on molecular diagnostics of squamous and salivary gland tumors of head and neck. Arch Pathol Lab Med. 2011;135:602–9.

    PubMed  Google Scholar 

  4. McCord C, Weinreb I, Perez-Ordonez B. Progress in salivary gland pathology: new entities and selected molecular features. Diagnostic Histopathol. 2012;18(6):253–60.

    Article  Google Scholar 

  5. Skalova A, Vanecek T, Simpson RHW, Michal M. Molecular advances in salivary gland pathology and their practical application. Diagnostic Histopathol. 2012;18(9):388–96.

    Article  Google Scholar 

  6. Skalova A, Vanecek T, Sima R, Laco J, Weinreb I, Perez-Ordonez B, Starek I, Geierova M, Simpson RHW, Passador-Santos F, Ryska A, Leivo I, Kinkor Z, Michal M. Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 2010;34:599–608.

    PubMed  Google Scholar 

  7. Tognon C, Knezevich SR, Huntsman D, Roskelley CD, Melnyk N, Mathers JA, Becker L, Carneiro F, MacPherson N, Horsman D, Poremba C, Sorensen PHB. Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell. 2002;2:367–76.

    Article  PubMed  CAS  Google Scholar 

  8. Fehr A, Loning T, Stenman G. Mammary analogue secretory carcinoma of the salivary glands with ETV6-NTRK3 gene fusion. Letter to Editor. Am J Surg Pathol 2011; 35: 1600–1602.

    Google Scholar 

  9. Griffith C, Seethala R, Chiosea SI. Mammary analogue secretory carcinoma: a new twist to the diagnostic dilemma of zymogen granule poor acinic cell carcinoma. Virchows Arch. 2011;459:117–8.

    Article  PubMed  Google Scholar 

  10. Lei Y, Chiosea SI. Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools. Head and Neck Pathol. 2012;6:166–70.

    Article  Google Scholar 

  11. Connor A, Perez-Ordoñez B, Shago M, Skálová A, Weinreb I. Mammary analog secretory carcinoma of salivary gland origin with the ETV6 gene rearrangement by FISH: expanded morphologic and immunohistochemical spectrum of a recently described entity. Am J Surg Pathol. 2012;36:27–34.

    Article  PubMed  Google Scholar 

  12. Chiosea SI, Griffith C, Assad A, Seethala RR. The profile of acinic cell carcinoma after recognition of mammary analog secretory carcinoma. Am J Surg Pathol. 2012;36:343–50.

    Article  PubMed  Google Scholar 

  13. Chiosea SI, Griffith C, Assad A, Seethala RR. Clinicopathological characterization of mammary analogue carcinoma of salivary glands. Histopathology. 2012;61:387–94.

    Article  PubMed  Google Scholar 

  14. Schwarz S, Zenk J, Muller M, Ettl T, Wunsch PH, Hartmann A, Agaimy A. The many faces of acinic cell carcinomas of the salivary glands: a study of 40 cases relating histological and immunohistological subtypes to clinical parameters and prognosis. Histopathology. 2012;61:395–408.

    Article  PubMed  Google Scholar 

  15. Rastatter JC, Jatana KR, Jennings LJ, Melin-Aldana H. Mammary analogue secretory carcinoma of parotid gland in a pediatric patient. Otolaryngol Head Neck Surg. 2012;146:514–5.

    Article  PubMed  Google Scholar 

  16. Petersson F, Lian D, Chau YP, Yan B. Mammary analogue secretory carcinoma: the first submandibular case reported including findings on fine needle aspiration cytology. Head Neck Pathol. 2012;6:135–9.

    Article  PubMed  Google Scholar 

  17. Ito S, Ishida E, Skalova A, Matsuura K, Kumamoto H, Sato I. Short communication: a case of mammary analogue secretory carcinoma of parotid gland. Pathol Internat. 2012;62:149–52.

    Article  CAS  Google Scholar 

  18. Levine P, Fried K, Krevitt LD, Wang B, Wenig BM. Aspiration biopsy of mammary analogue secretory carcinoma of accessory parotid gland: another diagnostic dilemma in matrix-containing tumors of the salivary glands. Diagn Cytopathol 2012.

  19. Kratochvil FJ, Stewart JCB, Moore SR. Mammary analog secretory carcinoma of salivary glands: a report of 2 cases in the lip. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:630–5.

    Article  PubMed  Google Scholar 

  20. Laco J, Švajdler M, Jr, Andrejs J, Hrubala D, Hácová M, Vaněček T, Skálová A, Ryška A. Mammary analogue secretory carcinoma of salivary glands: a report of 2 cases with expression of basal/myoepithelial markers (calponin, CD10 and p63 protein). Pathol Res Pract 2013- in press.

  21. Chenevert J, Duvvuri U, Chiosea S, Dacic S, Cieply K, Kim J, Shiwarski D, Seethala RR. DOG1: a novel marker of salivary acinar and intercalated duct differentiation. Mod Pathol. 2012;25:919–29.

    Article  PubMed  CAS  Google Scholar 

  22. Griffith CC, Stelow EB, Saqi A, Khalbuss WE, Schneider F, Chiosea SI, Seethala R. The cytological features of mammary analogue secretory carcinoma. A series of 6 molecularly confirmed cases. Cancer Cytopathol. 2013;121:234–41.

    Article  PubMed  CAS  Google Scholar 

  23. Tognon CE, Somasiti AM, Evdokimova VE, et al. ETV6-NTRK3-mediated breast epithelial cell transformation is blocked by targeting the IGF1R signaling pathway. Cancer Res. 2011;71:1060–70.

    Article  PubMed  CAS  Google Scholar 

  24. Behboudi A, Enlund F, Winnes M, Andrén Y, Nordkvist A, Leivo I, Flaberg E, Szekely L, Mäkitie A, Grenman R, Mark J, Stenman G. Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene. Genes Chromosomes Cancer. 2006;45:470–81.

    Article  PubMed  CAS  Google Scholar 

  25. Moller E, Stenman G, Mandahl N, Hamberg H, Molne L, van den Oord JJ, Brosjo O, Mertens F, Panagopoukos I. POU5FI, encoding a key regulator of stem cell pluripotency, is fused to EWSRI in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands. J Pathol. 2008;215:78–86.

    Article  PubMed  CAS  Google Scholar 

  26. Persson M, Andrén Y, Mark J, Horlings HM, Persson F, Stenman G. Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proc Natl Acad Sci USA. 2009;106:18740–4.

    Article  PubMed  CAS  Google Scholar 

  27. Antonescu C, Katabi N, Zhang L, Sung YS, Seethala RR, Jordan RC, Perez-Ordonez B, Have C, Asa SL, Leong IT, Bradley G, Klieb H, Weinreb I. EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland. Genes Chromosomes Cancer. 2011;50(7):559–70.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Sikl’s Department of Pathology, Faculty of Medicine in Pilsen, Faculty Hospital, Medical Faculty of Charles University, E. Benese 13, 305 99, Plzen, Czech Republic

    Alena Skalova

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  1. Alena Skalova
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Correspondence to Alena Skalova.

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Skalova, A. Mammary Analogue Secretory Carcinoma of Salivary Gland Origin: An Update and Expanded Morphologic and Immunohistochemical Spectrum of Recently Described Entity. Head and Neck Pathol 7 (Suppl 1), 30–36 (2013). https://doi.org/10.1007/s12105-013-0455-y

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  • DOI: https://doi.org/10.1007/s12105-013-0455-y

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