Abstract
A peptide or a small protein released from an exocrine gland or in urine is utilized as a chemosignal that elicits social or reproductive behavior in mice. Recently, we identified the male-specific peptide, exocrine gland-secreting peptide 1 (ESP1), in mouse tear fluids that enhanced female sexual receptive behavior, and determined the three dimensional structure. ESP1 appears to be a member of multigene family that consists of 38 genes in mice, which we call the ESP family. ESP4, a member of the ESP family, is expressed in various exocrine glands, and shows the highest sequence similarity with ESP1. Here, we report the NMR assignments of ESP4 which provides a basis for NMR analyses of this protein. Our results will give insight into structural relationships within the ESP family.
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Acknowledgments
We gratefully acknowledge H. Kimoto for helpful discussions. This work was supported by the Targeted Proteins Research Program (TPRP), and the Grants-in-Aid for Scientific Research on Priority Areas (19036022) from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and by the Grants-in-Aid for Young Scientists (B) (24780104) and the Grants-in-Aid JSPS Fellows (222339) from the Japan Society for the Promotion of Science.
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Taniguchi, M., Yoshinaga, S., Haga-Yamanaka, S. et al. Backbone and side-chain 1H, 15N and 13C assignments of mouse peptide ESP4. Biomol NMR Assign 8, 7–9 (2014). https://doi.org/10.1007/s12104-012-9441-7
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DOI: https://doi.org/10.1007/s12104-012-9441-7