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CRHR1 Gene SNPs and Response to Systemic Corticosteroids in Indian Asthmatic Children During Acute Exacerbation

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Abstract

Objective

To determine association of corticotrophin releasing hormone receptor 1 (CRHR1) gene single nucleotide polymorphisms (SNPs), rs242939 (A>G) and rs242941 (G>T) with response to systemic corticosteroids in North Indian asthmatic children during acute exacerbation.

Methods

This was a hospital based cross-sectional study. Sixty-eight children aged 1 to 12y with acute exacerbation of asthma were included in the study. The study was approved by the institutional ethics committee and written informed consent was obtained from parents/guardians of recruited children. GINA guidelines 2008, were used for classification and treatment of acute exacerbation of asthma. As per the GINA guidelines 2008, children who had good response to injectable corticosteroid were classified as “Corticosteroid Responders” (CR). Rest of the children with incomplete or poor response to injectable corticosteroid were classified as “Corticosteroid Non Responders” (CNR).

Results

Among 68 hospitalized children, 45 (66.17 %) children were CR whereas 23 (33.83 %) children were CNR. On analyzing as dominant model, children with one or two copies of mutant allele of SNP rs242941 had statistically significant better response to systemic corticosteroid (OR = 5.00; 95 %CI = 1.32–19.64; p 0.013) as compared to children with no mutant allele.

Conclusions

Thus, CRHR1 gene SNP rs242941polymorphism is associated with better response to systemic corticosteroid during acute exacerbation of asthma.

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Contributions

SA: Responsible for conception, design, clinical examination, analysis and interpretation of data, drafting the article and revising it critically for important intellectual content; SG: Responsible for conception, design, acquisition of data, clinical examination, analysis, interpretation of data and drafting the article; SAg: Responsible for genetic analysis and interpretation of data; NS: Responsible for laboratory work. All of them were responsible for final approval of the version to be published. SA will act as guarantor for this paper.

Conflict of Interest

None

Source of Funding

Indian Council of Medical Research provided funds to carry out this study.

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Authors and Affiliations

  1. Department of Pediatrics, King George’s Medical University, Lucknow, Uttar Pradesh, 226003, India

    Shally Awasthi, Sarika Gupta, Sarita Agarwal & Neeraj Sharma

Authors
  1. Shally Awasthi
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  2. Sarika Gupta
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  3. Sarita Agarwal
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  4. Neeraj Sharma
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Corresponding author

Correspondence to Sarika Gupta.

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Awasthi, S., Gupta, S., Agarwal, S. et al. CRHR1 Gene SNPs and Response to Systemic Corticosteroids in Indian Asthmatic Children During Acute Exacerbation. Indian J Pediatr 82, 781–786 (2015). https://doi.org/10.1007/s12098-015-1702-x

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  • DOI: https://doi.org/10.1007/s12098-015-1702-x

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