Skip to main content
SpringerLink
Log in

Superior Mediastinal Syndrome : A Rare Presenting Feature of Acute Myeloid Leukemia

  • Clinical Brief
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Superior mediastinal syndrome (SMS) is an uncommon manifestation of malignant neoplastic disease in children. The commonest neoplastic cause of SMS is Non Hodgkin lymphoma. Acute myeloid leukemia (AML) as a cause of SMS is extremely uncommon in childhood. The authors hereby report a case of a child with AML who presented with SMS at their hospital. This report also highlights the importance of flowcytometry as a diagnostic modality in hematological malignancies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. O’Brien RT, Matlak ME, Condon VR, Johnson DG. Superior vena cava syndrome in children. West J Med. 1981;135:143–7.

    PubMed  Google Scholar 

  2. Gupta V, Srikanth RA, Pant P, Bhatia B. Superior vena cava syndrome in children Indian. J Hematol Blood Transfus. 2008;24:28–30.

    Article  Google Scholar 

  3. Liu HW, Wong KL, Chan TY, Lau CC, Liang R. Superior vena cava syndrome: a rare presenting feature of acute myeloid leukemia. Acta Haematol. 1988;79:213–6.

    Article  PubMed  CAS  Google Scholar 

  4. D’Angio GJ, Mius A, Evans AE. The superior mediastinal syndrome in children with cancer. Am J Roentgenol Radium Ther Nucl Med. 1965;93:537–44.

    Google Scholar 

  5. Arya LS, Narain S, Tomar S, Thavaraj V, Dawar R, Bhargawa M. Superior vena cava syndrome. Indian J Pediatr. 2002;69:293–7.

    Article  PubMed  CAS  Google Scholar 

  6. Golub TR, Arceci RJ. Acute myelogenous leukaemia. In: Pizzo PA, Poplack DG, eds. Principles and practice of pediatric oncology. Philadelphia, PA: Lippincott, Williams & Wilkins; 2006. pp. 591–644.

    Google Scholar 

  7. Gardella S, Cervantes F, Bladé J, Sánchez Bísonó J, Grañena A, Rozman C. Acute myeloblastic leukaemia presenting with superior vena cava syndrome due to mediastinal mass. Acta Haematol. 1984;71:174–7.

    Article  PubMed  CAS  Google Scholar 

  8. Ingram L, Rivera GH, Shapiro DN. Superior vena cava syndrome associated with childhood malignancy: analysis of 24 cases. Med Pediatr Oncol. 1990;18:476–81.

    Article  PubMed  CAS  Google Scholar 

  9. Tsai MH, Yang CP, Chung HT, Shih LY. Acute myeloid leukemia in a young girl presenting with mediastinal granulocytic sarcoma invading pericardium and causing superior vena cava syndrome. J Pediatr Hematol Oncol. 2009;31:980–2.

    Article  PubMed  Google Scholar 

  10. Shook D, Coustan-Smith E, Ribeiro RC, Rubnitz JE, Campana D. Minimal Residual Disease quantification in acute myeloid leukemia. Clin Lymphoma Myeloma. 2009;9:S281–5.

    Article  PubMed  Google Scholar 

Download references

Conflict of Interest

None.

Role of Funding Source

None.

Author information

Authors and Affiliations

  1. Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India

    Rachna Seth, Rishi Bolia & Richa Jain

  2. Department of Laboratory Oncology, DR. B.R.A.IRCH, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India

    Anita Chopra, Saroj Singh & Rajive Kumar

Authors
  1. Rachna Seth
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rishi Bolia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Richa Jain
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anita Chopra
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Saroj Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Rajive Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rachna Seth.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Seth, R., Bolia, R., Jain, R. et al. Superior Mediastinal Syndrome : A Rare Presenting Feature of Acute Myeloid Leukemia. Indian J Pediatr 80, 165–167 (2013). https://doi.org/10.1007/s12098-012-0799-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12098-012-0799-4

Keywords

Search

Navigation