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Efficacy and Safety of Saccharomyces boulardii in Acute Childhood Diarrhea: A Double Blind Randomised Controlled Trial

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Abstract

Objective

To see the efficacy and safety of 250 mg of Saccharomyces boulardii twice daily for 5 d in acute childhood diarrhea.

Methods

Children aged between 3 mo and 59 mo with acute onset diarrhea (of less than 48 h) admitted in DTTU (diarrhea treatment and training unit) were included and those with clinical evidence of severe malnutrition, systemic infection, encephalopathy and/or convulsion, electrolyte imbalance, invasive diarrhea or previous use of any probiotics were excluded from the study. Those included randomly were given either a placebo or Saccharomyces boullardi (SB) in identical packets mixed with puffed rice powder.

Results

Mean post intervention duration of diarrhea was significantly (95% CI = −28.13 to −5.43) shorter in SB group (52.08 ± 24.57 h) as compared to placebo group (64.04 ± 30.43 h). The time of appearance of first semi formed stool in SB group (39.48 ± 23.09 h) was significantly (95% CI −25.4 to −3.87) shorter than the placebo group (54.13 ± 28.21 h). No statistically significant difference was found in rest of the parameters.

Conclusions

There is initial evidence available that SB may have a therapeutic role in the management of acute childhood diarrhea.

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Authors and Affiliations

  1. Department of Pediatrics, Jawaharlal Nehru Medical College, AMU, Aligarh, UP, India

    Musheer Riaz & S. Manazir Ali

  2. Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, D1, Vasant Kunj, New Delhi, India

    Seema Alam

  3. Department of Microbiology, Jawaharlal Nehru Medical College, AMU, Aligarh, UP, India

    Abida Malik

Authors
  1. Musheer Riaz
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  2. Seema Alam
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  3. Abida Malik
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  4. S. Manazir Ali
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Correspondence to Seema Alam.

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Riaz, M., Alam, S., Malik, A. et al. Efficacy and Safety of Saccharomyces boulardii in Acute Childhood Diarrhea: A Double Blind Randomised Controlled Trial. Indian J Pediatr 79, 478–482 (2012). https://doi.org/10.1007/s12098-011-0573-z

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  • DOI: https://doi.org/10.1007/s12098-011-0573-z

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