Efficacy and Safety of Saccharomyces boulardii in Acute Childhood Diarrhea: A Double Blind Randomised Controlled Trial
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To see the efficacy and safety of 250 mg of Saccharomyces boulardii twice daily for 5 d in acute childhood diarrhea.
Children aged between 3 mo and 59 mo with acute onset diarrhea (of less than 48 h) admitted in DTTU (diarrhea treatment and training unit) were included and those with clinical evidence of severe malnutrition, systemic infection, encephalopathy and/or convulsion, electrolyte imbalance, invasive diarrhea or previous use of any probiotics were excluded from the study. Those included randomly were given either a placebo or Saccharomyces boullardi (SB) in identical packets mixed with puffed rice powder.
Mean post intervention duration of diarrhea was significantly (95% CI = −28.13 to −5.43) shorter in SB group (52.08 ± 24.57 h) as compared to placebo group (64.04 ± 30.43 h). The time of appearance of first semi formed stool in SB group (39.48 ± 23.09 h) was significantly (95% CI −25.4 to −3.87) shorter than the placebo group (54.13 ± 28.21 h). No statistically significant difference was found in rest of the parameters.
There is initial evidence available that SB may have a therapeutic role in the management of acute childhood diarrhea.
- Efficacy and Safety of Saccharomyces boulardii in Acute Childhood Diarrhea: A Double Blind Randomised Controlled Trial
The Indian Journal of Pediatrics
Volume 79, Issue 4 , pp 478-482
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- Print ISSN
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- Acute diarrhea
- Saccharomyces boularrdii
- Therapeutic role
- Industry Sectors
- Author Affiliations
- 1. Department of Pediatrics, Jawaharlal Nehru Medical College, AMU, Aligarh, UP, India
- 2. Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, D1, Vasant Kunj, New Delhi, India
- 3. Department of Microbiology, Jawaharlal Nehru Medical College, AMU, Aligarh, UP, India