Abstract
Purpose
To analyse the relationship between the transcriptional expression of Krüppel-like factor-6 (KLF6) and local response to treatment with radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC).
Methods
We determined the transcriptional expression of KLF6 in tumour biopsies obtained before treatment with radiotherapy in 83 HNSCC patients. The KLF6 expression was categorized according to the local control of the disease with a recursive partitioning analysis.
Results
During the follow-up period, 27 patients (32.5%) had a local recurrence of the tumour. Patients with local recurrence had significantly higher levels of KLF6 expression than patients in which radiotherapy achieved local control of the disease (P = 0.029). Five-year local recurrence-free survival for patients with a high transcriptional expression of KLF6 (n = 46) was 51.1% (95% CI 36.4–66.2%), and for patients with low expression it was 85.6% (95% CI 73.9–97.3%) (P = 0.0001). The results of a multivariate analysis showed that patients with a high KLF6 expression had a 3.8 times higher risk of local recurrence after treatment with radiotherapy (95% CI 1.4–10.5, P = 0.008).
Conclusion
Transcriptional expression of KLF6 was significantly related to local control in HNSCC patients treated with radiotherapy. Patients with high levels of KLF6 expression had a significantly higher risk of local recurrence after treatment.
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The data and materials are available from the corresponding author on request.
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Funding
This study was supported by a grant from Instituto de Salud Carlos III (FIS PI19/01661 to XL). Fondo Europeo de Desarrollo Regional (FEDER), A Way to Build Europe.
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The study was approved by the ethics committee of the Hospital de la Santa Creu i Sant Pau (No. IIBSP-CCC-2014-93).
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Informed consent for use of their specimens and data in this study was obtained from all adult patients.
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León, X., Venegas, M., Pujol, A. et al. Predictive value of transcriptional expression of Krüppel-like factor-6 (KLF6) in head and neck carcinoma patients treated with radiotherapy. Clin Transl Oncol 23, 2507–2512 (2021). https://doi.org/10.1007/s12094-021-02651-4
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DOI: https://doi.org/10.1007/s12094-021-02651-4