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Role of TIM-3 in ovarian cancer

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Abstract

Evidences have suggested that immunotherapy for ovarian cancer is effective. Immune checkpoints have emerged in the field of cancer immunotherapy. Multiple studies have shown negative regulation of TIM-3 expression on CD4+ and CD8+ T cells and other immunocytes. Overexpression of TIM-3 in innate immune cells has been found in certain types of tumor. The blockade of TIM-3 leads to sustained anti-tumor reactions. TIM-3 plays an inhibitive role for immunity in ovarian cancer. TIM-3 is involved in the development of various subtypes of ovarian cancer and thus has the potential to be a therapeutic target for treatment of ovarian cancer.

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Acknowledgements

This work was supported by grants from Society Development Plans, Department of Science and Technology Changzhou (CJ20159018 to Yun Xu). Besides, we also would like to thank Dr. Xiaofei Zhang and Dr. Xiaodong Li for their help in revising the manuscript.

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  1. Y. Xu, H. Zhang and Y. Huang have contributed equally to this work.

Authors and Affiliations

  1. Department of Gynecology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, Jiangsu Province, China

    Y. Xu, Y. Huang, X. Rui & F. Zheng

  2. Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA

    H. Zhang

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Correspondence to Y. Xu.

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Xu, Y., Zhang, H., Huang, Y. et al. Role of TIM-3 in ovarian cancer. Clin Transl Oncol 19, 1079–1083 (2017). https://doi.org/10.1007/s12094-017-1656-8

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