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Neutrophil to lymphocyte and platelet to lymphocyte ratios increase in ovarian tumors in the presence of frank stromal invasion

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Abstract

Objective

The aim of this study was to assess the predictive value of neutrophil/lymphocyte and platelet/lymphocyte ratios for borderline, malignant ovarian tumors, and borderline cases with microinvasion.

Methods

Totally 275 women with sonographically detected ovarian tumor were enrolled for this study. All subjects underwent gynecological surgery via endoscopic or conventional approach and ovarian masses were all evaluated histopathologically by the same pathologist. All study population was divided into three groups as group with borderline tumors, benign tumors, or malignant tumors according to the histopathological diagnosis. Just before surgical intervention, a blood sample was obtained from each participant to analyze CA125 level, neutrophil, platelet, and lymphocyte count.

Results

Neutrophil/lymphocyte ratio (AUC = 0.604, P = 0.02) was a significant predictor for malignant cases. Optimal cutoff value for the neutrophil/lymphocyte ratio was found to be 2.47 with 63.4 % sensitivity and 63.5 % specificity for malignancy prediction. Odds ratio of high neutrophil/lymphocyte ratio for malignancy risk was 2.5 (95 % CI 1.3–4.8, P = 0.004). Platelet/lymphocyte ratio (AUC = 0.621, P = 0.007) was a significant predictor for malignant cases. Platelet/lymphocyte ratio (AUC = 0.568, P = 0.05) was also predictive for cases without a benign mass. Optimal cutoff value for the platelet/lymphocyte ratio was found to be 144.3 with 54 % sensitivity and 59 % specificity for malignancy prediction. Odds ratio of high platelet/lymphocyte ratio for malignancy risk was 2.1 (95 % CI 1.1–3.8, P = 0.02).

Conclusion

Neutrophil/lymphocyte and platelet/lymphocyte ratios are predictors for malignant ovarian tumors but not borderline tumors even in case of microinvasion.

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Acknowledgments

We would like to thank all the patients and primary care physicians.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children’s Health Training and Research Hospital, Opr. Dr. Burhanettin Üstünel Cad. No:10, Üsküdar/Istanbul, Turkey

    M. Polat, T. Senol, E. Ozkaya, G. Ogurlu Pakay, M. S. Cikman, B. Konukcu, M. A. Ozten & A. Karateke

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  1. M. Polat
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  2. T. Senol
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  3. E. Ozkaya
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  4. G. Ogurlu Pakay
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  5. M. S. Cikman
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  6. B. Konukcu
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  7. M. A. Ozten
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  8. A. Karateke
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Corresponding author

Correspondence to E. Ozkaya.

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The authors have declared that no conflict of interest exists.

Signed informed consent was obtained from all the participants.

This study complies with the latest Declaration of Helsinki for Researches involving Human Participants and/or Animals.

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Polat, M., Senol, T., Ozkaya, E. et al. Neutrophil to lymphocyte and platelet to lymphocyte ratios increase in ovarian tumors in the presence of frank stromal invasion. Clin Transl Oncol 18, 457–463 (2016). https://doi.org/10.1007/s12094-015-1387-7

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  • DOI: https://doi.org/10.1007/s12094-015-1387-7

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