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Tumor-associated macrophages in cancers

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Abstract

Tumor-associated macrophages (TAMs) are major component of leukocytic infiltrate of tumors and play important roles in progression and regression of tumors. Tumor microenvironment determines the mutual conversion between M1 and M2 macrophages. In many kinds of tumors, M2 type macrophages are of the majority in TAMs and promote tumor progression and metastasis. The dynamic balance and interaction between TAMs and tumor cells have important effects on the occurrence and development of tumor. TAMs in malignant tumors are useful for clinical diagnosis and may provide a novel target for cancer treatment.

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Author contributions

The outline was conceived by Drs. Chang-Ping Wu and Jing-Ting Jiang. All authors participated in the preparation of the manuscript and contributed to initial drafts, edited version, and final version. All the authors read and approved the final version before submission.

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Authors and Affiliations

  1. Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, China

    W. Hu, X. Li, C. Zhang, Y. Yang & C. Wu

  2. Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, China

    W. Hu, X. Li, J. Jiang & C. Wu

  3. Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, China

    W. Hu, X. Li, J. Jiang & C. Wu

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  1. W. Hu
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W. Hu and X. Li are the co-first authors.

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Hu, W., Li, X., Zhang, C. et al. Tumor-associated macrophages in cancers. Clin Transl Oncol 18, 251–258 (2016). https://doi.org/10.1007/s12094-015-1373-0

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