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Nanoemulsions and nanoparticles for non-melanoma skin cancer: effects of lipid materials

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  • Advances in Translational Oncology
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Abstract

Basal cell carcinomas and squamous cell carcinomas are non-melanoma skin cancers reported to be among the most common malignancies, being responsible for high human morbidity. Conventional chemotherapy applied to these conditions shows non-specific targeting, thus severe adverse side effects are also commonly reported. New therapeutic strategies based on nanoparticulates technology have emerged as alternatives for site specific chemotherapy. Among the different types of nanoparticulates, lipid nanoemulsions and nanoparticles have several advantages for topical delivery of poorly soluble chemotherapeutics. These particles show sustained drug release and protection of loaded drugs from chemical degradation. This technology is promising to enhance the intracellular concentration of drugs and consequently reduce the cytotoxicity of skin chemotherapy.

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Acknowledgments

Dr. Patrícia Severino, Dr. Maria Helena A. Santana and Dr. Marco V. Chaud wish to acknowledge the sponsorship of the CAPES (Coordenação Aperfeiçoamento de Pessoal de Nível Superior) and FAPESP (Fundação de Amparo a Pesquisa do Estado de São Paulo). The authors wish to acknowledge Fundação para a Ciência e Tecnologia do Ministério da Ciência e Tecnologia, under the reference ERA-Eula/0002/2009.

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Authors and Affiliations

  1. Department of Biotechnological Processes, School of Engineering Chemical, University of Campinas-Unicamp, Campinas, 13083-970, Brazil

    P. Severino & M. H. A. Santana

  2. Faculty of Health Sciences, Fernando Pessoa University, Rua Carlos da Maia, 296, Office S.1, 4200-150, Porto, Portugal

    P. Severino, J. F. Fangueiro, S. V. Ferreira & E. B. Souto

  3. Department of Plastic Surgery, School of Medicine, University of Campinas-Unicamp, Campinas, 13083-970, Brazil

    R. Basso

  4. Laboratory for Development and Evaluation of Bioactive Substance, Sorocaba University (UNISO), Sorocaba, 18023-000, Brazil

    M. V. Chaud

  5. Department of Dermatology, Hospital Santo Antonio, CHP-EPE, Porto, Portugal

    A. Rosmaninho

  6. Institute of Biotechnology and Bioengineering, Centre of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro (IBB/CGB-UTAD), 5000-801, Vila Real, Portugal

    E. B. Souto

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  1. P. Severino
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Severino, P., Fangueiro, J.F., Ferreira, S.V. et al. Nanoemulsions and nanoparticles for non-melanoma skin cancer: effects of lipid materials. Clin Transl Oncol 15, 417–424 (2013). https://doi.org/10.1007/s12094-012-0982-0

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