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Co-expression of MMP-14 and MMP-19 predicts poor survival in human glioma

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Abstract

Aim

Matrix metalloproteinase (MMP)-14 and MMP-19 have been demonstrated to play an important role in the development of human gliomas. However, their prognostic values are not clear. The aim of this study was to investigate whether co-expression of MMP-14 and MMP-19 has prognostic relevance in human gliomas.

Methods

Immunohistochemistry and western blot were used to investigate the expression of MMP-14 and MMP-19 proteins in 128 patients with gliomas.

Results

The expression levels of MMP-14 and MMP-19 proteins in glioma tissues were both significantly higher (both P < 0.001) than those in non-neoplastic brain tissues according to the immunohistochemistry analysis, which was confirmed by the western blot analysis. Additionally, the overexpression of either MMP-14 or MMP-19 was significantly associated with the advanced WHO grade (both P = 0.02), the low Karnofsky performance score (KPS) (P = 0.008 and 0.01, respectively) and the poor overall survival (both P = 0.01). Moreover, the Multivariate Cox proportional-hazards regression analysis revealed that the increased expressions of MMP-14 and MMP-19 were both independent prognostic factors for poor overall survival (both P = 0.02). Furthermore, the co-expression of MMP-14 and MMP-19 was additively and more significantly (P = 0.006) associated with adverse prognosis in patients with gliomas than respective expression of MMP-14 and MMP-19.

Conclusions

These findings indicated for the first time that the co-expression of MMP-14 and MMP-19 is significantly correlated with prognosis in glioma patients, suggesting that the co-expression of these proteins may be used as both an early diagnostic and independent prognostic marker.

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Acknowledgments

This work was funded by Natural Science Foundation of China (NO. 81101736).

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, 710038, People’s Republic of China

    Liang Wang, Shiming He & Jianhai Zong

  2. Administrative Department, Tangdu Hospital, Fourth Military Medical University, Xi’an, 710038, People’s Republic of China

    Jun Yuan & Yongsheng Zhang

  3. Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, 710038, People’s Republic of China

    Yanyang Tu & Guoqiang Fu

  4. Department of Neurosurgery, 254th Hospital of PLA, Tianjin, 300142, People’s Republic of China

    Xinggang Mao

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  1. Liang Wang
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  2. Jun Yuan
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  4. Xinggang Mao
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  5. Shiming He
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  7. Jianhai Zong
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  8. Yongsheng Zhang
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Corresponding author

Correspondence to Yongsheng Zhang.

Additional information

L. Wang, J. Yuan and Y. Tu contributed equally to this work.

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Wang, L., Yuan, J., Tu, Y. et al. Co-expression of MMP-14 and MMP-19 predicts poor survival in human glioma. Clin Transl Oncol 15, 139–145 (2013). https://doi.org/10.1007/s12094-012-0900-5

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  • DOI: https://doi.org/10.1007/s12094-012-0900-5

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