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Immunohistochemical expression of cyclooxygenase-2 in patients with advanced cancer of the larynx who have undergone induction chemotherapy with the intention of preserving phonation

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Abstract

Introduction

Cyclooxygenase-2 (COX2) is an enzyme that plays a role in different stages of the carcinogenic process and has prognostic and predictive values that have not yet been established. The objective of this study was to evaluate the role of COX2 overexpression in advanced squamous cell carcinoma of the larynx that has been treated with a phonation conservation protocol.

Materials and methods

This study included a retrospective analysis of 59 patients with resectable tumours that were treated with chemotherapy (CT) and/or radiation therapy (RT). The expression levels of COX2, epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and vascular endothelial growth factor receptor (VEGFR-2) in collected biopsy specimens were determined via immunohistochemistry.

Results

Forty-four percent of the included samples demonstrated overexpression of COX2. In the statistical analysis, COX2 overexpression did not correlate with other clinical or treatment efficacy prognostic factors; however, the median global survival (OS) of patients whose tumours expressed COX2 was 79 months, whereas COX2-negative patients had a median OS of only 38 months, although this finding did not reach statistical significance. The other analysed biological parameters did not demonstrate a significant relationship with COX2.

Conclusions

COX2 overexpression was a common finding in our study. The results obtained did not reveal relationships with established prognostic categories; however, the difference in survival between patients with and without COX2 expression justifies the need for future prospective studies that utilise a larger patient sample size.

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References

  1. Rodrigo Tapia JP (2002) Incidencia y etiología de los carcinomas de cabeza y cuello. In: Suárez Nieto C (ed) Oncología de cabeza y cuello. Medicina stm, Barcelona, pp 1–14

  2. The Department of Veterans Affairs Laryngeal Cancer Study Group (1991) Induction chemotherapy plus radiotherapy compared with surgery plus radiotherapy in patients with advances laryngeal cancer. N Engl J Med 324:1685–1690

    Article  Google Scholar 

  3. Schantz SP, Harrison LB, Forastiere AA (1997) Tumors of the nasal cavity and paranasal sinuses, nasophatrinx, oral cavity and oropharynx. In: De vita VT, Hellman S, Rosenberg SA (eds) Principles of oncology, 5th edn. Lippincott, Philadephia, pp 741–801

  4. Liu CH, Chang SH, Narko K et al (2001) Over-expression of cyclooxigenasa (Cox)-2 is sufficient to induce tumorigenesis in transgenic. Biol Chem 276:18563–18569

    Article  CAS  Google Scholar 

  5. Masferrer JL, Leía KM, Kaki AT et al (2000) Antiogenic and antitumor activities of cyclooxygenase 2 inhibitors. Cancer Res 60:1306–1311

    PubMed  CAS  Google Scholar 

  6. Ristimaki A, Sivula A, Lunfin J et al (2002) Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res 62:632–635

    PubMed  CAS  Google Scholar 

  7. Shim JY et al (2003) Overexpression of cyclooxigenase-2 is associated with breast carcinoma and its poor prognostic factor. Mod Pathol 16:1199–1204

    Article  PubMed  Google Scholar 

  8. Sano H, Kawahito Y, Wilder RL et al (1995) Expresión of cyclooxigenase-1 and -2 in human colorectal cancer. Cancer Res 55:3789–3789

    Google Scholar 

  9. Yoshimatsu K, Nasser K, Golijanin D et al (2001) Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer. Clin Cancer Res 7:2669–2674

    PubMed  CAS  Google Scholar 

  10. Karmali RA, Wustrow T, Thaler HT, Strong EW (1984) Prostaglandins in carcinomas of the head and neck. Cancer Lett 22:333–336

    Article  PubMed  CAS  Google Scholar 

  11. Jung TK, Berlinger NT, Juhn SK (1985) Prostaglandins in squamous cell of the head and neck: a preliminary study. Laryngoscope 95:307–312

    Article  PubMed  CAS  Google Scholar 

  12. Tsujii M, Kawano S, Tsuji S et al (1998) Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93:705–716

    Article  PubMed  CAS  Google Scholar 

  13. Rueda A, Cazorla O, Pérez L et al (2011) Vascular endotelial growth factor and vascular endotelial growth factor receptor-2 tumor expresión in patients with advanced laryngeal cancer alter induction chemotherapy for organ preservation. Head Neck 33:808–816

    Article  PubMed  Google Scholar 

  14. Kyzas PA, Stefanou D, Agnantis NJ (2005) COX-2 expression correlates with VEGF-C and lymph node metastases in patients with head and neck squamous cell carcinoma. Mod Pathol 18:153–160

    Article  PubMed  CAS  Google Scholar 

  15. Xu CZ, Dong P, Li XY et al (2009) Expression and clinical significante of hypoxia-inducible factor-1alpha and cyclooxigenase-2 in laryngeal squamous cell carcinoma. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 44:57–62

    Google Scholar 

  16. Fosslien E (2000) Molecular pathology of cyclooxigenase-2 in neoplasia. Ann Clin Lab Sci 30:3–21

    PubMed  CAS  Google Scholar 

  17. Tsujii M, DuBois RN (1995) Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 83:493–501

    Article  PubMed  CAS  Google Scholar 

  18. Dohadwala M, Luo J, Zhu L et al (2001) Non-small cell lung cancer cyclo-oxigenase 2 dependent invasión is mediated by CD44. j. Biol Chem 276:809–812

    Google Scholar 

  19. Davies G et al (2003) Correlation between cyclooxigenase-2 expression and angiogenesis in human breast cancer. Clin Cancer Res 9:2651–2656

    PubMed  CAS  Google Scholar 

  20. Ranelletti FO et al (2001) Prognostic significance of cyclooxygenase-2 in laryngeal squamous cell carcinoma. Int J Cancer 95:343–349

    Article  PubMed  CAS  Google Scholar 

  21. Sackett MK, Bairati I, Meyer F et al (2008) Prognostic significance of cyclooxygenase-2 overxpression in glottis cancer. Clin Cancer Res 14:67–73

    Article  PubMed  CAS  Google Scholar 

  22. Cho EI, Kowalski DP, Sasaki CT et al (2004) Tissue microarray analysis reveals prognostic significance of COX-2 expression for local relapse in T1–2N0 larynx cancer treated with primary radiation therapy. Laryngoscope 114:2001–2008

    Article  PubMed  CAS  Google Scholar 

  23. Danneberg AJ, Altorki NK, Boyle JO et al (2001) Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer. Lancet Oncol 2:544–551

    Article  Google Scholar 

  24. Soo R, Putti T, Tao Q et al (2005) Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with epidermal growth factor receptor expression. Arch Otolaryngol Head Neck Surg 131:147–152

    Article  PubMed  Google Scholar 

  25. Qin G, Liang Q, Yu L et al (2010) Expression and significance of COX-2 and S-100 positive dendritic cell in laryngeal carcinoma. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 24:101–104

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Acknowledgments

This work was partially supported by Fondo de Investigaciones Sanitarias (FIS 09/910, Spain).

Conflict of interest

There are no conflict of interests.

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Authors and Affiliations

  1. Division of Medical Oncology, Oncology department, Hospital Costa del Sol, Autovía A-7, Km 187, C. P. 29603, Marbella, Malaga, Spain

    Elisabeth Pérez-Ruiz & A. Rueda

  2. Division of Otolaryngology, Antequera, Málaga, Spain

    O. Cazorla

  3. Department of Biochemistry, CIBER ESP, Hospital Costa del Sol, Marbella, Spain

    M. Redondo

  4. Department of Pathological Anatomy, Hospital Virgen de la Victoria, Málaga, Spain

    L. Pérez, M. Álvarez, E. Gallego & A. Matilla

  5. Division of Medical Oncology, Hospital Virgen de la Victoria, Málaga, Spain

    J. M. Trigo

  6. Division of Radiotherapy, Hospital Virgen de la Victoria, Málaga, Spain

    J. A. Medina

Authors
  1. Elisabeth Pérez-Ruiz
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  2. O. Cazorla
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  3. M. Redondo
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  4. L. Pérez
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  5. M. Álvarez
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  6. E. Gallego
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  7. J. M. Trigo
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  8. J. A. Medina
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  9. A. Matilla
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  10. A. Rueda
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Corresponding author

Correspondence to Elisabeth Pérez-Ruiz.

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Pérez-Ruiz, E., Cazorla, O., Redondo, M. et al. Immunohistochemical expression of cyclooxygenase-2 in patients with advanced cancer of the larynx who have undergone induction chemotherapy with the intention of preserving phonation. Clin Transl Oncol 14, 682–688 (2012). https://doi.org/10.1007/s12094-012-0859-2

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  • DOI: https://doi.org/10.1007/s12094-012-0859-2

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