Educational Series

Clinical and Translational Oncology

, Volume 9, Issue 9, pp 563-570

First online:

Peptidomimetics in cancer chemotherapy

  • C. AvendañoAffiliated withDepartamento de Química Orgánica y Farmacéutica, Universidad Complutense Email author 
  • , J. C. MenéndezAffiliated withDepartamento de Química Orgánica y Farmacéutica, Universidad Complutense

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Abstract

A summary of the current status of the application of peptidomimetics in cancer therapeutics as an alternative to peptide drugs is provided. Only compounds that are used in therapy or at least under clinical trials are discussed, using inhibitors of farnesyltransferase, proteasome and matrix metalloproteinases as examples.

Key words

Farnesyltransferase inhibitors Ras Metalloproteinase inhibitors Angiogenesis Proteasome inhibitors