Hepatology International

, Volume 8, Supplement 2, pp 439–446

Immunity and inflammatory signaling in alcoholic liver disease

Authors

    • Department of MedicineUniversity of Massachusetts Medical School
  • Aditya Ambade
    • Department of MedicineUniversity of Massachusetts Medical School
Supplement Issue: ALPD

DOI: 10.1007/s12072-014-9518-8

Cite this article as:
Mandrekar, P. & Ambade, A. Hepatol Int (2014) 8: 439. doi:10.1007/s12072-014-9518-8

Abstract

The pathogenesis of alcoholic liver disease (ALD) is multifactorial and characterized by steatosis, steatohepatitis and cirrhosis. Several signaling pathways in different liver cell types that contribute to the development and progression of alcoholic liver injury have been identified. Among these, immune cells and signaling pathways are the most prominent and central to ALD. Both innate and adaptive immune responses contribute to ALD. The key features of inflammatory pathways in ALD including liver innate and adaptive immune cell types, signaling receptors/pathways, and pro- and antiinflammatory/protective responses are summarized here.

Keywords

ALDASHHepatic inflammationPRRsCytokinesImmunity

Copyright information

© Asian Pacific Association for the Study of the Liver 2014