Supplement Issue: ALPD

Hepatology International

, Volume 8, Supplement 2, pp 439-446

First online:

Immunity and inflammatory signaling in alcoholic liver disease

  • Pranoti MandrekarAffiliated withDepartment of Medicine, University of Massachusetts Medical School Email author 
  • , Aditya AmbadeAffiliated withDepartment of Medicine, University of Massachusetts Medical School

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The pathogenesis of alcoholic liver disease (ALD) is multifactorial and characterized by steatosis, steatohepatitis and cirrhosis. Several signaling pathways in different liver cell types that contribute to the development and progression of alcoholic liver injury have been identified. Among these, immune cells and signaling pathways are the most prominent and central to ALD. Both innate and adaptive immune responses contribute to ALD. The key features of inflammatory pathways in ALD including liver innate and adaptive immune cell types, signaling receptors/pathways, and pro- and antiinflammatory/protective responses are summarized here.


ALD ASH Hepatic inflammation PRRs Cytokines Immunity