Original Article

Hepatology International

, Volume 8, Issue 1, pp 64-71

Nucleoside analogs prevent disease progression in HBV-related acute-on-chronic liver failure: validation of the TPPM model

  • Junshuai WangAffiliated withDepartment and Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
  • , Ke MaAffiliated withDepartment and Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
  • , Meifang HanAffiliated withDepartment and Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
  • , Wei GuoAffiliated withDepartment and Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
  • , Jiaquan HuangAffiliated withDepartment and Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
  • , Daofeng YangAffiliated withDepartment and Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
  • , Xiping ZhaoAffiliated withDepartment and Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
  • , Jiangxin SongAffiliated withDepartment and Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
  • , Deying TianAffiliated withDepartment and Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
    • , Junying QiAffiliated withDepartment and Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
    • , Yuancheng HuangAffiliated withDepartment and Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology Email author 
    • , Qin NingAffiliated withDepartment and Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology Email author 

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Abstract

Purpose

This study aimed to evaluate the efficacy and safety of entecavir, lamivudine and telbivudine for treating patients with HBV-ACLF and to validate the Tongji prognostic predictor model (TPPM) in these patients.

Methods

In this retrospective study, we enrolled 283 patients with HBV-ACLF (100 treated with entecavir, 98 treated with lamivudine and 85 treated with telbivudine). There were no significant differences in baseline clinical and virological characteristics among patients treated with entecavir, telbivudine or lamivudine.

Results

There were no significant differences in the 4- and 12-week survival rates of entecavir-, telbivudine- and lamivudine-treated patients (79.00, 81.18 and 86.73 %, respectively, at 4 weeks; 67.00, 65.88 and 73.47 %, respectively, at 12 weeks). Patients in all three groups achieved an improvement in the model for end-stage liver disease (MELD) score. Using the Hosmer-Lemeshow test, the validation of the TPPM score for HBV-ACLF demonstrated a good degree of fit with disease prognosis. Based on this unique group of patients, the TPPM score with an AUC of 0.787 was superior to the MELD score, which had an AUC of 0.736 in the prediction of 12-week mortality. The TPPM had an AUC of 0.733, and the MELD score had an AUC of 0.672 in the prediction of 4-week mortality. Using a cutoff value of 0.22 for 12-week mortality prediction by the TPPM, the positive predictive value was 49.66 %, with a negative predictive value of 89.55 %.

Conclusion

Treatment with nucleoside analogs including entecavir, lamivudine and telbivudine prevented disease progression and increased the survival of patients with HBV-ACLF. Validation of the established TPPM scoring system in this study confirmed its superior predictive value for HBV-ACLF patients when compared with the MELD system.

Keywords

HBV-ACLF Antiviral therapy Nucleoside analogs MELD TPPM