Skip to main content
SpringerLink
Log in

Central recruitment in individual with auditory neuropathy

  • Original Article
  • Published:
Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Auditory neuropathy (AN) describes patients with dysfunction of the auditory nerve in the presence of preserved cochlear outer hair-cell receptor functions in presence of normal otoacoustic emissions and/or cochlear microphonics. In individuals with auditory neuropathy speech are disproportionate to their hearing sensitivity and reported to be dependent on cortical evoked potentials. In individuals with AN, who have normal cortical potentials have better speech identification scores when compared to those with abnormal cortical potentials reflect relation between the cortical potentials and the speech identification scores. One group comparison research design was used for present study. The purpose of the study was to compare shift in latency of LLR peaks at different sensation level in subjects with auditory neuropathy and age matched normal individuals. 6 subjects (11 ears) diagnosed as having auditory neuropathy and 6 subjects (12 ears) with normal hearing Sensitivity participated for the study. Pure tone audiometry, immittance, reflexometry and otoacoustic emissions were administered. ABR was recorded for all the subjects at a repetition rate of 11.1 at an intensity of 90 dB nHL. LLR was carried out at different intensity levels for/da/speech stimulus at an intensity of 90 dB nHL. Latency of N1 and P2 of LLR was calculated at different sensation levels for both the groups. Descriptive analysis was carried out to find out the mean and standard deviation for latency of N1 and P2 for both, AN and normal hearing group. There was delay in latency of N1 and P2 for individuals with auditory neuropathy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Carhart R, Jerger J (1959) Preferred method of clinical determination of pure tone threshold. J speech hear Disord 24(330):345

    Google Scholar 

  2. Cody DT, Griffing T, Taylor WF (1968) Assessment of the newer tests of auditory function. Ann Otol Rhinol Laryngol 77:686–705

    Article  PubMed  CAS  Google Scholar 

  3. Kraus N, Mcgee T, Ferre J, Hoeppner J, Sharma A, Carrell T, Nicol T (1993) Mismatch negativity in the neurophysiological/behaveoralevaluation of auditory processing deficits:a case study. Ear Hear 14:223–234

    Article  PubMed  CAS  Google Scholar 

  4. Kraus N, Bradlow A, Chetham M, Cunningham J, King C et al (2000) Consequences of a neural asynchrony: a case of auditory neuropathy. J Assoc Res Otolaryngol 1:33–45

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  5. Michalewski H, Starr A, Nguyen T, Kong Y, Zeng F (2005) Auditory temporal processes in normal-hearing individuals and in patients with auditory neuropathy. Clin Neurophysiol 116:669–680

    Article  PubMed  Google Scholar 

  6. Narne V, Vanaja C (2008) Speech identifi cation and cortical potentials in individuals with auditory neuropathy. Behav Brain Funct 4:15

    Article  PubMed  PubMed Central  Google Scholar 

  7. Rance G, Cone-Wesson B, Wunderlich J, Dowell R (2002) Speech perception and cortical event related potentials in children with auditory neuropathy. Ear Hear 23:239–253

    Article  PubMed  Google Scholar 

  8. Starr A et al (1991) Absence of both auditory evoked potentials and auditory percepts dependent on timing cues. Brain 114:1157–1180

    Article  PubMed  Google Scholar 

  9. Salvi RJ, Wang J, Ding D (2000) Auditory plasticity and hyperactivity following cochlear damage. Hear Res 147:261–274

    Article  PubMed  CAS  Google Scholar 

  10. Starr A, Picton TW, Sininger Y, Hood L, Berlin C (1996) Auditory neuropathy. Brain 119:741–753

    Article  PubMed  Google Scholar 

  11. Starr A, Michalewski HJ, Zeng FG, FujiKawa-Brooks S, Lithicum F, Kim CS, Winner D, Keats B (2003) Pathology and physiology of AN with novel mutation in the MPZ gene (tyr145- > ser). Brain 126:1604–1619

    Article  PubMed  Google Scholar 

  12. Starr A, Isaacson B, Michalewski HJ, Zeng FG, Kong YY, Beale P, Paulson GW, Keats BJ, Lesperance MM (2004) A dominantly inherited progressive deafness affecting distal auditory nerve and hair cells. J Assoc Res Otolaryngol 5:411–426

    Article  PubMed  PubMed Central  Google Scholar 

  13. Satya-Murthi S, Wolpaw JR, Cacace AT, Scharffer CA (1983) Late auditory evoked potentials can occur without brain stem potentials. Electroencephalogr Clin Neurophysiol 56(4):304–308

    Article  Google Scholar 

  14. Vanaja CS, Manjula P (2004) LLR as a measure of benefit derived from hearing devices with auditory dys-synchrony. In first conference on Auditory Neuropathy In: Shivashanker N, Shashikala HR (eds) Bangalore: Department of Speech pathology and Audiology, National Institute of Mental Health and Neuro sciences 136–146

  15. Zeng FG, Oba S, Starr A. (2000) Suprathreshold processing deficits due to desynchronous neural activities in auditory neuropathy. In: Breebaart DJ, Houstma AJM, Kohlrausch A, et al (eds) Physiological and psychophysical bases of auditory function. Maastricht: Shaker. p 365–372

Download references

Acknowledgment

We would like to thank director of Pt.JNM Medical college, Raipur and HOD of ENT department Dr. BRAM Hospital, who allowed to carry out the research and to all the participants for their cooperation.

Author information

Authors and Affiliations

  1. Audiology and Speech Language Pathology Unit, Department of ENT, Pt.J.N.M.Medical College, Ayush Health science University, Raipur, 492001, Chhattisgarh, India

    Preeti Sahu, Rajkishor Mishra, Debadatta Mahallik, Imran Ansari & Varsha Mungutwar

Authors
  1. Preeti Sahu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rajkishor Mishra
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Debadatta Mahallik
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Imran Ansari
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Varsha Mungutwar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Preeti Sahu.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sahu, P., Mishra, R., Mahallik, D. et al. Central recruitment in individual with auditory neuropathy. Indian J Otolaryngol Head Neck Surg 66, 455–459 (2014). https://doi.org/10.1007/s12070-014-0767-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12070-014-0767-6

Keywords

Search

Navigation