, Volume 15, Issue 6, pp 538-547
Date: 10 Aug 2010

How to protect the chromosomal ends?

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Abstract

The 2009 Nobel Prize in Physiology or Medicine was jointly awarded to three scientists — Elizabeth H Blackburn, Carol W Greider and Jack W Szostak — for their work during early 1980s and 1990s which helped unravel the molecular mechanisms of protection of chromosomal ends by telomeres and the enzyme telomerase. Their discovery has had major implications in the fields of ageing and cancer research. Blackburn and Greider are the ninth and tenth women scientist, to get this award in physiology or medicine and this is the first time that two women scientists have shared the prize.

Anurag N Paranjape is a research scholar working in the laboratories of Annapoorni Rangarajan, IISc, and Geetashree Mukherjee, Kidwai Memorial Institute of Oncology, Bangalore. His areas of interest include understanding the mechanisms of immortalization and transformation of human mammary stem cells.
Annapoorni Rangarajan is an Assistant Professor at the Indian Institute of Science, Bangalore. The major focus of research in her laboratory is to understand the mechanisms of carcinogenesis. Currently her lab is exploring the mechanisms of self-renewal in normal and cancerous stem cells.