General / Article

Resonance

, Volume 15, Issue 6, pp 538-547

How to protect the chromosomal ends?

Telomerase, chromosome stability and aging
  • Anurag N. ParanjapeAffiliated withDepartment of Molecular Reproduction, Development and Genetics (MRDG), Indian Institute of Science Email author 
  • , Annapoorni RangarajanAffiliated withDepartment of Molecular Reproduction, Development and Genetics (MRDG), Indian Institute of Science

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Abstract

The 2009 Nobel Prize in Physiology or Medicine was jointly awarded to three scientists — Elizabeth H Blackburn, Carol W Greider and Jack W Szostak — for their work during early 1980s and 1990s which helped unravel the molecular mechanisms of protection of chromosomal ends by telomeres and the enzyme telomerase. Their discovery has had major implications in the fields of ageing and cancer research. Blackburn and Greider are the ninth and tenth women scientist, to get this award in physiology or medicine and this is the first time that two women scientists have shared the prize.

Keywords

Chromosomes telomeres telomerase immortalization cancer Nobel Prize in Physiology or Medicine