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Increasing litter size in a sheep breed by marker-assisted selection of BMPR1B A746G mutation

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References

  • Chu M. X., Ji C. L. and Chen G. H. 2003 Association between PCR-RFLP of melatonin receptor 1a gene and high prolificacy in Small Tail Han sheep. Asian-Aust. J. Anim. Sci. 16, 1701–1704.

  • Chu M. X., Liu Z. H., Jiao C. L., He Y. Q., Fang L., Ye S. C. et al. 2007 Mutations in BMPR-IB and BMP-15 genes are associated with litter size in Small Tailed Han sheep (Ovis aries). J. Anim. Sci. 85, 598–603.

  • Chu M., Jia L., Zhang Y., Jin M., Chen H., Fang L. et al. 2011 Polymorphisms of coding region of BMPR-IB gene and their relationship with litter size in sheep. Mol. Biol. Rep. 38, 4071–4076.

  • Davis G. H. 2004 Fecundity genes in sheep. Anim. Reprod. Sci 82–83, 247–253.

  • Davis G. H. 2005 Major genes affecting ovulation rate in sheep. Genet. Sel. Evol. 37, 11–23.

  • Davis G. H., Balakrishnan L., Ross I. K., Wilson T., Galloway S. M., Lumsden B. M. et al. 2006 Investigation of the Booroola (FecB) and Inverdale (FecX(I)) mutations in 21 prolific breeds and strains of sheep sampled in 13 countries. Anim. Reprod. Sci. 92, 87–96.

  • Fogarty N. M. 2009 A review of the effects of the Booroola gene (FecB) on sheep production. Small Ruminant Res. 85, 75–84.

  • Guan F., Liu S. R., Shi G. Q. and Yang L. G. 2007 Polymorphism of FecB gene in nine sheep breeds or strains and its effects on litter size, lamb growth and development. Anim. Reprod. Sci. 99, 44–52.

  • Kumar S., Kolte A. P., Mishra A. K., Arora A. L. and Singh V. K. 2006 Identification of the FecB mutation in Garole × Malpura sheep and its effect on litter size. Small Ruminant Res. 64, 305–10.

  • Liu S. F., Yan Y. C. and Du L. X. 2003 Advances on localization and molecular mechanism of FecB gene. Yi Chuan 25, 93–6.

  • Mulsant P., Lecerf F., Fabre S., Schibler L., Monget P., Lanneluc I. et al. 2001 Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Merino ewes. Proc. Natl. Acad. Sci. USA 98, 5104–9.

  • Roy J., Polley S., De S., Mukherjee A., Batabyal S., Pan S. et al. 2011 Polymorphism of fecundity genes (FecB, FecX, and FecG) in the Indian Bonpala sheep. Anim. Biotechnol. 22, 151–62.

  • Sambrook J. and Russell D. 2001 Molecular cloning. a laboratory manual. 3rd edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, USA.

  • Wilson T., Wu X. Y., Juengel J. L., Ross I. K., Lumsden J. M., Lord E. A. et al. 2001 Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells. Biol. Reprod. 64, 1225–35.

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Acknowledgements

This work was supported by the Domain-Specific Projects for Transgenic Biological Breeding (2013ZX08009-002), Science and Technology Support Programme of Hebei province (06220402D-3), and the Agricultural Science and Technology Achievements Transformation Projects of Hebei province (11220139D). The authors thank Jicai Jiang (China Agricultural University) for data analysis.

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Authors and Affiliations

  1. College of Animal Science and Technology, China Agricultural University, Beijing, 100193, People’s Republic of China

    XIAOYONG CHEN, HAI XIANG & XINGBO ZHAO

  2. Institute of Animal Science and Veterinary of Hebei Province, Baoding, 071000, People’s Republic of China

    XIAOYONG CHEN, HONGXIN SUN & WEITAO DUN

  3. College of Animal Science and Technology, Agricultural University of Hebei, Baoding, 071000, People’s Republic of China

    SHUJUN TIAN

  4. Hebei Liansheng Agricultural Development Company Limited, Baoding, 072750, People’s Republic of China

    LIANSHENG ZHOU

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  1. XIAOYONG CHEN
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  2. HONGXIN SUN
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  3. SHUJUN TIAN
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  4. HAI XIANG
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  5. LIANSHENG ZHOU
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  6. WEITAO DUN
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  7. XINGBO ZHAO
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Corresponding authors

Correspondence to WEITAO DUN or XINGBO ZHAO.

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[Chen X., Sun H., Tian S., Xiang H., Zhou L., Dun W. and Zhao X. 2015 Increasing litter size in a sheep breed by marker-assisted selection of BMPR1B A746G mutation. J. Genet. 94, xx–xx]

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CHEN, X., SUN, H., TIAN, S. et al. Increasing litter size in a sheep breed by marker-assisted selection of BMPR1B A746G mutation. J Genet 94, 139–142 (2015). https://doi.org/10.1007/s12041-015-0470-8

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  • DOI: https://doi.org/10.1007/s12041-015-0470-8

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