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Recognition of self-assembled water-nitrate cluster in a Co(III)-2,2′-bipyridine host: Synthesis, X-ray structure, DNA cleavage, molecular docking and anticancer activity

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Abstract

A mononuclear cobalt(III) complex [Co(bpy)2Cl2]NO3⋅2H2O (1) (bpy = 2,2′-bipyridine) has been synthesized and crystallographically characterized. Self-assembly of the lattice water molecules from rectangular tetrameric water cluster interacts with nitrate anion along the c-axis forming a six membered hexagonal water-nitrate cluster. It presents a new mode of association of water molecules with nitrate molecules which is not predicted theoretically or found experimentally. The molecule effectively cleaves bacterial genomic DNA and shows important cytotoxicity against human hepatocarcinoma cell (HepG2).

This paper reports an X-ray crystallographic characterization of a Co(III)-bpy complex which also presents a new mode of association of water molecules with nitrate molecules which was not predicted theoretically or found experimentally or reported in literature. The molecule effectively cleaves bacterial genomic DNA and shows important cytotoxicity against human hepatocarcinoma cell (HepG2).

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Acknowledgements

DD thanks the Science & Engineering Research Board (SERB), New Delhi for fellowship to him. The work is supported financially by SERB, India under the FAST TRACK SCHEME for YOUNG SCIENTIST (No. SB/FT/CS-088/2013 dtd. 21/05/2014). BB sincerely thanks Dr. P. S. Guin and Dr. S. Roy, Department of Chemistry, Shibpur Dinobundhoo Institute (College), Howrah 711102, West Bengal for the electrochemical data of the cobalt(III) complex.

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Author notes

  1. SUBHASISH SAHA

    Present address: Present Address: Post Doctoral Fellow, Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China

Authors and Affiliations

  1. Department of Chemistry, Raghunathpur College, Purulia, West Bengal, 723 133, India

    SUBRATA DAS & BHASKAR BISWAS

  2. Department of Microbiology, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620 024, India

    ANANDAN RANJANI, LOGANATHAN GAYATHRI, SUBHASISH SAHA & DHARUMADURAI DHANASEKARAN

  3. Mahatma Gandhi-Doerenkamp Center, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620 024, India

    LOGANATHAN GAYATHRI & MOHAMMAD ABDULKADER AKBARSHA

  4. Institut de Ciencia Molecular (ICMol), Universidad de Valencia, Catedrático José Beltrán 2, 46980, Paterna, Valencia, Spain

    JORGE PASAN

  5. Department of Chemistry, National Institute of Technology, Mahatma Gandhi Avenue, Durgapur, West Bengal, 713 209, India

    MILAN MAJI

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Correspondence to BHASKAR BISWAS.

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Supplementary Information (SI)

Supplementary crystallographic data are available free of charge from The Director, CCDC, 12 Union Road, Cambridge, CB2 1EZ, UK (fax: + 44-1223-336033; E-mail: deposit@ccdc.cam.ac.uk or www: http://www.ccdc.cam.ac.uk) upon request, quoting deposition number CCDC 825244. FTIR, UV-Vis spectra, ESI-MS, supramolecular interactions, TGA diagram and table of hydrogen bonded parameters (Figures S1 – S10 and Tables S1 and S2) are given in Supplementary Information, available at www.ias.ac.in/chemsci.

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DAS, S., RANJANI, A., GAYATHRI, L. et al. Recognition of self-assembled water-nitrate cluster in a Co(III)-2,2′-bipyridine host: Synthesis, X-ray structure, DNA cleavage, molecular docking and anticancer activity. J Chem Sci 128, 1755–1764 (2016). https://doi.org/10.1007/s12039-016-1167-0

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  • DOI: https://doi.org/10.1007/s12039-016-1167-0

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