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Impact of the PPAR gamma-2 gene polymorphisms on the metabolic state of postmenopausal women

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Abstract

The relationship Pro12Ala (rs1801282) and C1431T (rs3856806) polymorphisms of PPAR gamma-2 with glucose and lipid metabolism is not clear after menopause. We investigated the impact of the Pro12Ala and C1431T silent substitution in the 6th exon in PPAR gamma-2 gene on nutritional and metabolic status in 271 postmenopausal women (122 lean and 149 obese). The general linear model (GLM) approach to the two-way analysis of variance (ANOVA) was used to infer the interactions between the analysed genotypes. The frequency of the Pro-T haplotype was higher in obese than in lean women (p<0.0349). In the analysed GLM models according to obesity status, the C1431C genotype was related to a lower glucose concentration (β=−0.2103) in lean women, and to higher folliculotropic hormone FSH levels (β=0.1985) and lower waist circumferences (β=−0.1511) in obese women. The influence of C1431C was present regardless of the occurrence of the Pro12Ala polymorphism. The co-existence of the C1431C and Pro12Pro genotypes was related to lower values for triceps skinfold thickness compared those for the T1241/X and Ala12/X polymorphisms (β=−0.1425). The presence of C1431C decreased the differences between triceps values that were determined by Pro or Ala allele. In conclusion, C1431T polymorphism seems to have a more essential influence on anthropometric and biochemical parameters than is the case with Pro12Ala polymorphism.

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Acknowledgements

This work was supported by the Polish National Science Centre (NSC) under the Grant No. N404 504 638.

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Authors and Affiliations

  1. Department of Bromatology and Human Nutrition, Poznan University of Medical Sciences, Poznan, Poland

    Bogna Grygiel-Górniak & Juliusz Przysławski

  2. Department of Rheumatology and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland

    Bogna Grygiel-Górniak

  3. Department of Molecular Pathology, Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland

    Maria Mosor & Jerzy Nowak

  4. Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland

    Justyna Marcinkowska

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  1. Bogna Grygiel-Górniak
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  2. Maria Mosor
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  3. Justyna Marcinkowska
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  4. Juliusz Przysławski
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  5. Jerzy Nowak
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Correspondence to Bogna Grygiel-Górniak.

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[Grygiel-Górniak B, Mosor M, Marcinkowska J, Przysławski J and Nowak J 2016 Impact of the PPAR gamma-2 gene polymorphisms on the metabolic state of postmenopausal women. J. Biosci.]

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Grygiel-Górniak, B., Mosor, M., Marcinkowska, J. et al. Impact of the PPAR gamma-2 gene polymorphisms on the metabolic state of postmenopausal women. J Biosci 41, 427–437 (2016). https://doi.org/10.1007/s12038-016-9633-x

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  • DOI: https://doi.org/10.1007/s12038-016-9633-x

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