Abstract
A recent genome-wide association study conducted in Caucasians has identified glutaminyl-peptide cyclotransferase (QPCT) gene as a susceptibility gene for schizophrenia, as its common single nucleotide polymorphism (SNP) rs2373000 was significantly associated with the risk of this disease. To date, this finding has not been validated in other populations or ethnic groups. The aim of this study was to investigate the association of common SNPs spanning QPCT gene with the susceptibility of schizophrenia in a Han Chinese population comprising 440 schizophrenia patients and 450 control subjects. A total of 6 tagSNPs including rs2373000 was selected and then genotyped in our sample. Although the relation between rs2373000 and the risk of schizophrenia was not successfully replicated, we showed for the first time that the minor allele (C) of rs3770752 was associated with a reduced risk of schizophrenia (odds ratio (OR) = 0.645; 95 % confidence interval (CI) 0.486–0.855; P corrected = 0.012) in our cohorts. Meanwhile, this allele seemed to modify the schizophrenia risk through a dominant manner (CC + CT vs. TT, OR = 0.625; 95 % CI 0.457–0.854; P corrected = 0.03). In addition, we found that the minor allele (T) of rs3770748 remarkably reduced the schizophrenia risk via a recessive manner (TT vs. TC + CC, OR = 0.618; 95 % CI: 0.449–0.851; P corrected = 0.03). Taken together, these findings demonstrate a significant association between common SNPs within QPCT gene and schizophrenia risk in a Han Chinese population, suggesting QPCT gene may represent a susceptibility gene for this disease.
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This work was supported by the National Natural Science Foundation of China to T.J. (81501092), the Natural Science Foundation of Jiangsu Province to T.J. (BK20150091) and Y.D.Z. (BK20151084), and the China Postdoctoral Science Foundation to T.J. (2015 M580448).
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Qiao-Quan Zhang and Teng Jiang should be regarded as co-first authors.
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ESM 1
Supplementary Table S1. General information of tSNPs within QPCT in our samples. (DOC 44 kb)
ESM 2
Supplementary Table S2. Comparison of genotypes and allele frequencies of tSNPs within QPCT between control subjects from the exploratory and replication samples and those obtained from the HapMap database. (DOC 53 kb)
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Zhang, QQ., Jiang, T., Gu, LZ. et al. Common Polymorphisms Within QPCT Gene Are Associated with the Susceptibility of Schizophrenia in a Han Chinese Population. Mol Neurobiol 53, 6362–6366 (2016). https://doi.org/10.1007/s12035-015-9541-3
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DOI: https://doi.org/10.1007/s12035-015-9541-3