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Thrombomodulin and High-Sensitive C-Reactive Protein Levels in Blood Correlate with the Development of Cerebral Infarction Among Asians

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Abstract

Our meta-analysis was designed to obtain the correlation between thrombomodulin (TM) and high-sensitive C-reactive protein (hs-CRP) levels and the development of cerebral infarction (CI). Case–control studies relevant to the role plasma TM levels and serum hs-CRP levels in the development of CI were retrieved both electronically and manually and further screened according to a predetermined inclusion and exclusion criteria. All enrolled studies were analyzed for meta-regression analyses, sensitivity analyses, and assessments of publication bias. Comprehensive Meta-analysis 2.0 software (CMA 2.0) was used for statistical analysis. A total of 359 studies were initially retrieved, and 13 studies were eventually recruited into our meta-analysis with a total of 881 CI patients (plasma TM levels: n = 513; serum hs-CRP levels: n = 368) and 1067 healthy controls. The results of our meta-analysis suggested that plasma TM levels and serum hs-CRP levels in CI patients were significantly higher than those in healthy controls. In conclusion, increased plasma TM levels and serum hs-CRP levels in CI patients were associated with the development of CI in Asians.

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Acknowledgments

We would like to appreciate the reviewers for their helpful comments on this paper. This study was funded by National Natural Science Foundation of China (81100847, 81401127), Shanghai Natural Science Foundation (13ZR1460500), Shanghai Pujiang Program (14PJC002), and the excellent backbone project of Hongkou District in Shanghai.

Conflict of Interest

The authors have proclaimed no existing competing interests.

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Authors and Affiliations

  1. Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China

    Yan Han & Shuai Wu

  2. Department of Psychology, Qiqihar Mental Health Center, Qiqihar, 161000, China

    Qiang Hu

  3. Department of Neurosurgery, The First Hospital of Qiqihar City, Qiqihar, 161000, China

    Jian-Qi Xiao

  4. Department of Traditional Chinese Medicine, The First Hospital of Qiqihar City, Qiqihar, 161000, China

    Dong-Mei Wei

  5. Department of Neurology, Shanghai Houkou District Jiangwan Hospital, Shanghai, China

    Li-Li Liu

  6. Department of Neurology, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

    Ze-Zhi Li

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  1. Yan Han
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Correspondence to Li-Li Liu or Ze-Zhi Li.

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Yan Han and Shuai Wu both are co-first authors.

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Han, Y., Wu, S., Hu, Q. et al. Thrombomodulin and High-Sensitive C-Reactive Protein Levels in Blood Correlate with the Development of Cerebral Infarction Among Asians. Mol Neurobiol 53, 2659–2667 (2016). https://doi.org/10.1007/s12035-015-9279-y

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