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The Natural Flavonoid Pinocembrin: Molecular Targets and Potential Therapeutic Applications

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Abstract

Pinocembrin is a natural flavonoid compound extracted from honey, propolis, ginger roots, wild marjoram, and other plants. In preclinical studies, it has shown anti-inflammatory and neuroprotective effects as well as the ability to reduce reactive oxygen species, protect the blood-brain barrier, modulate mitochondrial function, and regulate apoptosis. Considering these pharmaceutical characteristics, pinocembrin has potential as a drug to treat ischemic stroke and other clinical conditions. In this review, we summarize its pharmacologic characteristics and discuss its mechanisms of action and potential therapeutic applications.

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Acknowledgments

This work was supported by an AHA Mid-Atlantic Affiliate Grant-in-Aid 13GRNT15730001 and NIH grants K01AG031926, R01NS078026, and R01AT007317. We thank Claire Levine, MS, ELS, for editorial assistance and the Wang lab members for insightful discussions.

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The authors declare no conflict of interest.

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  1. Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross Bldg 370B, Baltimore, MD, 21205, USA

    Xi Lan, Wenzhu Wang, Qiang Li & Jian Wang

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Correspondence to Jian Wang.

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Lan, X., Wang, W., Li, Q. et al. The Natural Flavonoid Pinocembrin: Molecular Targets and Potential Therapeutic Applications. Mol Neurobiol 53, 1794–1801 (2016). https://doi.org/10.1007/s12035-015-9125-2

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