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Clinical utility of measuring expression levels of Stanniocalcin 2 in patients with colorectal cancer

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Abstract

Stanniocalcin 2 (STC2) is a novel member of the Stanniocalcin family, the function of which remains unclear. Its expression is clinically significant in several cancers. The aim of this study was to evaluate the clinical value of measuring expression levels of STC2 in colorectal cancer (CRC) patients. A total of 47 tumor and matched tumor-free margin samples were obtained during surgery. The STC2 mRNA expression level in tumor and marginal tissue was examined by real-time quantitative PCR. STC2 mRNA expression levels were higher in tumor tissues than the control. (r = 0.36, p ≤ 0.02). mRNA expression level of STC2 was significantly associated with tumor size (p ≤ 0.05) and histologic grade (p ≤ 0.05). Our study demonstrated that STC2 was significantly expressed in CRC patients, relative to the control. STC2 can therefore be used as a biomarker to differentiate between tumor borders and margins. Analysis of STC2 gene expression during surgery could be useful in reducing surgical error in tumor removal and increasing overall success of surgery with improved tumor clearance. However, in some cases such as where the tumor is end-stage, the expression of such a biomarker may not be clinically beneficial to record. The consideration of marginal samples as a control group can help reduce the effect of confounding factors such as racial and individual differences.

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Authors and Affiliations

  1. Liver and Gastrointestinal Disease Research Center and Department of General and Thoracic Surgery, Tabriz University of Medical Sciences, Tabriz, Iran

    Shahryar Hashemzadeh & Amir Ahmad Arabzadeh

  2. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Mehrdad Asghari Estiar

  3. Faculty of Medicine, University of Liverpool, Liverpool, UK

    Masoud Sakhinia

  4. Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Nahid Mesbahi

  5. Tuberculosis and Lung Disease Research Center and Department of Medical Genetics, Faculty of Medicine, Tabriz Genetic Analysis Center (TGAC), Tabriz University of Medical Sciences, Tabriz, Iran

    Leila Emrahi & Ebrahim Sakhinia

  6. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Morteza Ghojazadeh

Authors
  1. Shahryar Hashemzadeh
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  2. Amir Ahmad Arabzadeh
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  3. Mehrdad Asghari Estiar
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  4. Masoud Sakhinia
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  8. Ebrahim Sakhinia
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Correspondence to Ebrahim Sakhinia.

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Hashemzadeh, S., Arabzadeh, A.A., Estiar, M.A. et al. Clinical utility of measuring expression levels of Stanniocalcin 2 in patients with colorectal cancer. Med Oncol 31, 237 (2014). https://doi.org/10.1007/s12032-014-0237-8

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  • DOI: https://doi.org/10.1007/s12032-014-0237-8

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