Abstract
The outcome is variable for unresectable locally advanced non-small-cell lung cancer (ULANSCLC) patients treated with radio(chemo)therapy. The aim of this study is to investigate whether single-nucleotide polymorphisms (SNPs) in the transforming growth factor-beta1 (TGF-β1) gene are associated with overall survival (OS) in ULANSCLC patients treated with definitive radio(chemo)therapy. A total of 109 patients who had available blood samples and complete clinical and follow-up information were enrolled. DNA from blood was genotyped for two SNPs: TGF-β1 C-509T and T+869C. Kaplan–Meier survival analysis, log-rank test, and Cox’s proportional hazard model were used to evaluate associations between genotypes and OS. Log-rank test showed that TGF-β1 C-509T significantly correlated with OS (pooled P = 0.017). Both univariate and multivariate analyses showed that TGF-β1 C-509T CC genotype was significantly associated with better OS than CT or TT genotypes. These results indicate that TGF-β1 C-509T CC genotype is significantly associated with better OS in ULANSCLC patients treated with radio(chemo)therapy as a potential independent survival predictor.
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Acknowledgments
This research was supported by Wenzhou Science and Technology Bureau of China (Grants No. 2011S0057). We thank Dr. Jing Zhao for her assistance in genotyping and statistical analysis of the data.
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The authors declare that they have no competing interests.
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Xue, SL., Zheng, YH., Su, HF. et al. Association between single nucleotide polymorphisms of the transforming growth factor-beta1 gene and overall survival in unresectable locally advanced non-small-cell lung cancer patients treated with radio(chemo)therapy in a Chinese population. Med Oncol 30, 512 (2013). https://doi.org/10.1007/s12032-013-0512-0
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DOI: https://doi.org/10.1007/s12032-013-0512-0