January 2013, 30:389
Date: 19 Jan 2013
Association analyses of osteoprotegerin gene polymorphisms with bone mineral density in Chinese postmenopausal women
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Osteoprotegerin gene (OPG) is an important candidate gene of osteoporosis. The objective of this study was to evaluate the association between OPG gene polymorphisms and bone mineral density (BMD). A total of 336 Chinese postmenopausal women were included in this study. OPG gene polymorphisms were detected by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP), created restriction site–PCR (CRS–PCR) and DNA sequencing methods. BMD was evaluated at the lumbar spine (L2–4), total hip and femoral neck. Two single-nucleotide polymorphisms (SNPs) (g.21775C>T and g.23367T>C) were identified and the association analysis showed significant difference of spine BMD among different g.23367T>C genotype, subjects with the genotype TT was significantly higher than those of genotype TC and CC. Such a significant difference was not observed at the neck hip BMD and total hip BMD. The g.21775C>T polymorphism was not significantly associated with spine BMD, total hip BMD and neck hip BMD in the studied subjects. These findings suggested that OPG gene polymorphisms were associated with BMD in Chinese postmenopausal women. Results from this study will be helpful in further studies to determine the role of OPG gene in osteoporosis.
Feng Zhang and Chunlei He contributed equally to this paper.
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- Association analyses of osteoprotegerin gene polymorphisms with bone mineral density in Chinese postmenopausal women
- Online Date
- January 2013
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Association analysis
- Bone mineral density
- Osteoprotegerin gene
- Postmenopausal women
- Single-nucleotide polymorphisms
- Industry Sectors
- Author Affiliations
- 1. Orthopedics Department, The Second Affiliated Hospital Zhejiang University College of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, People’s Republic of China
- 2. Department of Orthopedics, The First Affiliated Hospital of Gannan Medical University, No. 23, Qingnian Road, Ganzhou, 341000, Jiangxi Province, People’s Republic of China