Abstract
Alveolar soft part sarcoma (ASPS) is a rare mesenchymal tumor, accounting for <1 % of all soft tissue sarcomas. It appears mainly in young adults, has a female predominance and follows an indolent natural history. Like other sarcomas, it can metastasize to the lungs, liver, bones and the brain, but unusual sites have also been described, including the vagina, the orbit, colonic mucosa and the breast. This paper presents a case report of a 31-year-old patient with metastatic ASPS, who developed two highly vascular breast nodules that following an excisional biopsy, were shown to represent metastases from the patient’s known sarcoma.
Similar content being viewed by others
References
Toombs BD, Kalisher L. Metastasic disease of the breast: clinical, pathological and radiographic features. AJR Am J Roentgenol. 1997;129:673–6.
Vergier B, Trojani M, De Mascarel I, et al. Metastases to the breast: differential diagnosis from primary breast carcinoma. J Surg Oncol. 1991;48:l12–116.
Amichetti M, Perani B, Boi S. Metastases to the breast from extramammary malignancies. Oncology. 1990;47:257–60.
Surov A, Fiedler E, Holzhausen HJ, Ruschke K, Schmoll HJ, Spielmann RP. Metastases to the breast from non-mammary malignancies: primary tumors, prevalence, clinical signs, and radiological features. Acad Radiol. 2011;18(5):565–74.
D’Angelo P, Carli M, Ferrari A, et al. Breast metastases in children and adolescents with rhabdomyosarcoma: experience of the Italian soft tissue sarcoma committee. AIEOP Soft Tissue Sarcoma Committee. Pediatr Blood Cancer. 2010;55(7):1306–9.
Auerbach HE, Brooks JJ. Alveolar soft part sarcoma: a clinicopathologic and immunohistochemical study. Cancer. 1987;60:66–73.
Portera CA Jr, Ho V, Patel SR, et al. Alveolar soft part sarcoma: clinical course and patterns of metastasis in 70 patients treated at a single institution. Cancer. 2001;91:585–91.
Anderson ME, Hornicek FJ, Gebhardt MC, Raskin KA, Mankin HJ. Alveolar soft part sarcoma: a rare and enigmatic entity. C lin Orthop Relat Res. 2005;438:144–8.
Reichardt P, Lindner T, Pink D, Thuss-Patience PC, Kretzschmar A, Dörken B. Chemotherapy in alveolar soft part sarcomas. What do we know? Eur J Cancer. 2003;39(11):1511–6.
Lieberman PH, Brennan MF, Kimmel M, Erlandson RA, Garin-Chesa P, Flehinger BY. Alveolar soft-part sarcoma. A clinico-pathologic study of half a century. Cancer 1989.1;63(1):1–13.
Madrigrano A, Beach B, Wheeler A, Wapnir I. Metastases to the breast: alveolar soft part sarcoma in adolescents. Clin Breast Cancer. 2008;8(1):92–3.
Van Buren R, Stewart J 3rd. Alveolar soft part sarcoma presenting as a breast mass in a 13-year-old female. Diagn Cytopathol. 2009;37(2):122–4.
Muzumdar GA, Murthy AK. Bilateral mammary metastasis of alveolar soft part sarcoma-a case report. Indian J Pathol Microbiol. 1996;39(4):325–7.
Şahan EK, Bilgiç B, Kuşku E, Çelik E, Erdoğan N. Alveolar soft part sarcoma, metastasis in breast. Case report. www.apocp.net/congress2010/abstract/words/344.doc.
Cho SY, Lee HC, Kim CJ, Kim MS, Park SH, Ham EK, Park IA. Bilateral mammary metastasis of alveolar soft part sarcoma. A case report. Korean J Pathol. 2003;37:365–8.
Hanna NN, O’Donnell K, Wolfe GR. Alveolar soft part sarcoma metastatic to the breast. J Surg Oncol. 1996;61(2):159–62.
Lim HS, Heo SH, Park JG, Kang HK. Metastatic alveolar soft part sarcoma of the breast. J Ultrasound Med. 2006;25(7):929–32.
Weiss SW, Goldblum JR. Enzinger and Weiss’s Soft Tissue Tumors. 5th ed. Philadelphia: Mosby Elsevier; 2008.
Aulmann S, Longerich T, Schirmacher P, Mechtersheimer G, Penzel R. Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas. Histopathology. 2007;50(7):881–6.
Conflict of interest
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Orphanos, G., Ioannidis, G., Ioannou, R. et al. Alveolar soft part sarcoma with breast metastases: a case report. Med Oncol 30, 342 (2013). https://doi.org/10.1007/s12032-012-0342-5
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s12032-012-0342-5